Evidence map›Paper›PMID 31955622›Full record

ArticleInnate immunity2020

Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease.

Kari Ann Shirey, Wendy Lai, Lindsey J Brown, Jorge C G Blanco, Robert Beadenkopf, Yajing Wang, Stefanie N Vogel, Greg A Snyder

Open access · goldAbstract read
In one paragraph

Article in Innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Evidence for Interplay Between the Renin-Angiotensin System and Toll-Like Receptor 4 Signaling Pathways in the Induction of Virus-Induced Acute Lung Injury.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kari Ann ShireyDepartment of Microbiology and Immunology, University of Maryland School of Medicine, USA.
Wendy LaiDepartment of Microbiology and Immunology, University of Maryland School of Medicine, USA.
Lindsey J BrownInstitute of Human Virology, Department of Medicine, University of Maryland School of Medicine, USA.
Jorge C G BlancoSigmovir Biosystems, Rockville, USA.
Robert BeadenkopfInstitute of Human Virology, Department of Medicine, University of Maryland School of Medicine, USA.
Yajing WangInstitute of Human Virology, Department of Medicine, University of Maryland School of Medicine, USA.
Stefanie N VogelDepartment of Microbiology and Immunology, University of Maryland School of Medicine, USA.
Greg A SnyderDepartment of Microbiology and Immunology, University of Maryland School of Medicine, USA.ORCID 0000-0002-4409-0453
University of Maryland, Baltimore · USSigmovir Biosystems (United States) · US

Funding

Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Eritoran (E5564), a TLR4 antagonist, as a novel therapeutic for influenzaR01AI104541 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANCO, JORGE C, VOGEL, STEFANIE N. · 2013 to 2016
$3.4M
Targeting TLR Signaling Pathways to Blunt Pathogen-mediated Acute Lung InjuryR01AI125215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANCO, JORGE C, VOGEL, STEFANIE N. · 2017 to 2021
$2.7M
Macrophage differentiation and disease outcome in influenza infectionR01AI123371 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI VOGEL, STEFANIE N. · 2017 to 2021
$2.7M
Therapeutic targeting of the B-cell lymphoma associated mutation MYD88-L265PR21CA191726 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI SNYDER, GREG ALLEN · 2015 to 2016
$395k
NCI NIH HHS R21 CA191726NIAID NIH HHS R01 AI104541NIAID NIH HHS R01 AI123371NIAID NIH HHS R01 AI125215NIAID NIH HHS T32 AI095190
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCrystallography, X-RayCysteineHEK293 CellsHumansImmunity, InnateInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMiceMice, Inbred C57BLModels, MolecularMutationOrthomyxoviridae InfectionsProtein ConformationProtein DomainsSulfonamidesCysteineethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateSulfonamidesToll-Like Receptor 4influenzaInnate immunityToll-like receptor

Identifiers

PMID31955622
PMCPMC6974880
OpenAlexW3001718486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.