Evidence map›Paper›PMID 31955406›Full record

ArticleActa obstetricia et gynecologica Scandinavica2020

External validation and clinical utility of prognostic prediction models for gestational diabetes mellitus: A prospective cohort study.

Linda J E Meertens, Hubertina C J Scheepers, Sander M J van Kuijk, Nel Roeleveld, Robert Aardenburg, Ivo M A van Dooren, Josje Langenveld, Iris M Zwaan, Marc E A Spaanderman, Marleen M H J van Gelder and 1 more

Abstract readValidation Study
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Review
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  10. Adherence rates to a prediction tool identifying women with an increased gestational diabetes risk: An implementation study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Linda J E MeertensDepartment of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-4154-7737
Hubertina C J ScheepersDepartment of Obstetrics and Gynecology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Sander M J van KuijkDepartment of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center, Maastricht, The Netherlands.
Nel RoeleveldDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Robert AardenburgDepartment of Obstetrics and Gynecology, Zuyderland Medical Center, Heerlen, The Netherlands.
Ivo M A van DoorenDepartment of Obstetrics and Gynecology, Sint Jans Gasthuis Weert, Weert, The Netherlands.
Josje LangenveldDepartment of Obstetrics and Gynecology, Zuyderland Medical Center, Heerlen, The Netherlands.
Iris M ZwaanDepartment of Obstetrics and Gynecology, Laurentius Hospital, Roermond, The Netherlands.
Marc E A SpaandermanDepartment of Obstetrics and Gynecology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center, Maastricht, The Netherlands.
Marleen M H J van GelderDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Luc J M SmitsDepartment of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe performed an independent validation study of all published first trimester prediction models, containing non-invasive predictors, for the risk of gestational diabetes mellitus. Furthermore, the clinical potential of the best performing models was evaluated. MATERIAL AND

methodsSystemically selected prediction models from the literature were validated in a Dutch prospective cohort using data from Expect Study I and PRIDE Study. The predictive performance of the models was evaluated by discrimination and calibration. Clinical utility was assessed using decision curve analysis. Screening performance measures were calculated at different risk thresholds for the best model and compared with current selective screening strategies.

resultsThe validation cohort included 5260 women. Gestational diabetes mellitus was diagnosed in 127 women (2.4%). The discriminative performance of the 12 included models ranged from 68% to 75%. Nearly all models overestimated the risk. After recalibration, agreement between the observed outcomes and predicted probabilities improved for most models.

conclusionsThe best performing prediction models showed acceptable performance measures and may enable more personalized medicine-based antenatal care for women at risk of developing gestational diabetes mellitus compared with current applied strategies.

Indexed as

AlgorithmsAdultDiabetes, GestationalFemaleHumansModels, StatisticalNetherlandsPredictive Value of TestsPregnancyProbabilityPrognosisProspective StudiesRisk AssessmentRisk Factorsdecision curve analysisexternal validationgestational diabetes mellituspredictionrisk assessment

Identifiers

PMID31955406
PMCPMC7317858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.