Evidence map›Paper›PMID 31955339›Full record

ArticleJournal of assisted reproduction and genetics2020

Euploid rates among oocyte donors: is there an optimal age for donation?

Luis R Hoyos, Connie Y Cheng, Kathleen Brennan, Gary Hubert, Brandon Wang, Richard P Buyalos, Molly Quinn, Mousa Shamonki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Preimplantation Genetic Testing: Where We Are Today.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luis R HoyosDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA. lhoyosmartinez@mednet.ucla.edu.ORCID https://orcid.org/0000-0003-1276-4844
Connie Y ChengDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
Kathleen BrennanDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
Gary HubertDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
Brandon WangFertility and Surgical Associates of California, Thousand Oaks, CA, USA.
Richard P BuyalosDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
Molly QuinnDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
Mousa ShamonkiDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California, 10833 Le Conte Avenue, Room 27-139 CHS, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USUniversity Surgical Associates · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine cycle blastocyst euploid rates among age subgroups of oocyte donors.

methodsRetrospective cohort analysis of ova donation in vitro fertilization cycles (OD-IVF) for which trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) by array comparative genomic hybridization (aCGH) or next generation gene sequencing (NGS) was employed between January 2015 and December 2018 in a single high-volume fertility center.

resultsCompared to oocyte donors age 26-30, oocyte donors age ≤ 25 had similar cycle blastocyst euploid rates (80 [66.7, 87.5]%, vs. 75 [62.5, 87.5]%, median [IQR], p = 0.07), blastocyst formation rates (66.7 [50, 75]%, vs. 62.5 [52, 75]%, p = 0.55), and number of retrieved oocytes (29 [23, 37] vs. 27 [20, 35], p = 0.18). Age of oocyte donor from 18 to 34 was not correlated with cycle blastocyst euploid rate.

conclusionOocyte donors age ≤ 25 had similar cycle blastocyst euploid rates, blastocyst formation rates, and number of retrieved oocytes compared to donors age 26-30. There was no correlation between cycle blastocyst euploid rates and age of the oocyte donor from 18 to 34 years. Given the lack of significant age-related change in cycle blastocyst euploid rates, our data support existing practices which do not favor a specific age subgroup of young oocyte donors.

Indexed as

AneuploidyPreimplantation DiagnosisAbortion, SpontaneousAdultAge FactorsBlastocystComparative Genomic HybridizationEmbryo TransferFemaleFertilization in VitroHumansLive BirthOocyte DonationOocyte RetrievalOocytesOvulation InductionAgeAneuploidyEgg donorsEuploidIVFOocyte donorsPreimplantation genetic testing

Identifiers

PMID31955339
PMCPMC7125283
OpenAlexW2999928005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.