ArticleJournal of cancer research and clinical oncology2020
How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence.
Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea.World journal of gastroenterology · 2025Review
- Phytotherapy known and applied by head-neck cancer patients and medical students to treat oral discomfort in Germany: an observational study.Journal of cancer research and clinical oncology · 2023Observational
- Xerostomia: From Pharmacological Treatments to Traditional Medicine-An Overview on the Possible Clinical Management and Prevention Using Systemic Approaches.Current oncology (Toronto, Ont.) · 2023Review
- Indications of medical plants: what do medical students in Germany know? A cross-sectional study.Journal of cancer research and clinical oncology · 2022Article
- Experiences of patients who developed oral mucositis during solid neoplasms treatment: a Ugandan qualitative study.Journal of patient-reported outcomes · 2021Article
- How to transfer traditional knowledge about medicinal herbs? or TCM plants: a black box for modern oncologists.Journal of cancer research and clinical oncology · 2021Review
- Protective effect of kava constituents in an in vitro model of oral mucositis.Journal of cancer research and clinical oncology · 2020Article
- Medicinal Plants Used for Abdominal Discomfort - Information from Cancer Patients and Medical Students.In vivo (Athens, Greece)Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOral mucositis is a common, painful side effect of cancer treatment-be it locoregional (e.g. irradiation) or systemic (e. g. chemotherapy). Phytotherapy is often used by patients to alleviate symptoms. However, knowledge on which medical plants are recommended by literature about Traditional European Medicine (TEM), their effect(s) on symptoms and their efficacy is severely lacking. Therefore, we developed a novel approach to assess traditional knowledge of herbals used in TEM and searched the online databases for studies reporting effects of these plants.
methodsAt first, online research did not yield a satisfying number of studies (MESH terms: "mucositis" OR "stomatitis" AND "herbal" OR "herbal medicine"). Trials were labelled by the country conducting the study. In parallel, we compiled a list of 78 plants recommended for treating oral mucositis by screening 14 books on TEM. Then, a "hit list" of the plants most often mentioned was composed and used further for a second online investigation using the Latin plant designations as MESH term. Studies of both online searches were pooled for analysis.
resultsThere is a gap between traditional knowledge and trials investigating medical plants used by TEM. Overall, herbal remedies alleviate oral mucositis and especially, gingivitis well. There is good evidence for using Matricaria recutita L., Salvia officinalis L., Calendula officinalis L. and Thymus spp. L. for treating oral mucositis.
conclusionClinical trials investigating medical plants known in TEM are rare. However, following our research strategy, we could extrapolate four plants with good evidence for alleviating symptoms of oral mucositis and gingivitis.
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