Evidence map›Paper›PMID 31955222›Full record

ArticleActa neuropathologica2020

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Sven J van der Lee, Olivia J Conway, Iris Jansen, Minerva M Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernández, Kristel R van Eijk, Najada Stringa, Jason A Chen and 98 more

Abstract readPublished Erratum
In one paragraph

Article in Acta neuropathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

108 authors.

Sven J van der LeeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl.ORCID 0000-0003-1606-8643
Olivia J ConwayDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Iris JansenAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Minerva M CarrasquilloDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Luca KleineidamDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Erik van den AkkerMolecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Isabel HernándezResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Kristel R van EijkDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Najada StringaAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Jason A ChenInterdepartmental Program in Bioinformatics, University of California, Los Angeles, USA.
Anna ZettergrenNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.
Till F M AndlauerMax Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0002-2917-5889
Monica Diez-FairenMovement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.
Javier Simon-SanchezGerman Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.
Alberto LleóCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Marianne NygaardThe Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Cornelis BlauwendraatNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA.
Jeanne E SavageDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Jonas Mengel-FromEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Sonia Moreno-GrauResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Michael WagnerDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Juan ForteaCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Michael J KeoghInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Kaj BlennowClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Ingmar SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.
Manuel A FrieseGerman Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
Olga PletnikovaDepartment of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.
Miren ZulaicaCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Carmen LageCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Itziar de RojasResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany.
Ignacio Illán-GalaCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Wei WeiDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Bernard JeuneEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Adelina OrellanaResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Florian Then BerghGerman Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
Xue WangDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Marc HulsmanAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Nina BekerAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Niccolo TesiAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0002-1413-5091
Christopher M MorrisNewcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
Begoña IndakoetxeaCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Lyduine E CollijDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Martin SchererDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany.
Estrella Morenas-RodríguezCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
James W IronsideCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Bart N M van BerckelDepartment of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Daniel AlcoleaCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Heinz WiendlGerman Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
Samantha L StricklandDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Pau PastorMovement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain.
Eloy Rodríguez RodríguezCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
DESGESCO (Dementia Genetics Spanish Consortium)
EADB (Alzheimer Disease European DNA biobank)
IFGC (International FTD-Genomics Consortium)
IPDGC (The International Parkinson Disease Genomics Consortium)
RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia)
Netherlands Brain Bank (NBB)
Bradley F BoeveDepartment of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.
Tanis J FermanDepartment of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Jay A van GerpenDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Marcel J T ReindersDelft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
Ryan J UittiDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Lluís TárragaResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Wolfgang MaierDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Oriol Dols-IcardoCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Amit KawaliaDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
Maria Carolina DalmassoDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
Mercè BoadaResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Uwe K ZettlGerman Competence Network Multiple Sclerosis (KKNMS), Munich, Germany.
Natasja M van SchoorAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Marian BeekmanMolecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Mariet AllenDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Eliezer MasliahLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Adolfo López de MunainCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Alexander PantelyatDepartment of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Owen A RossDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
David KnopmanDepartment of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA.
Rosa RademakersDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Afina W LemstraAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Philip ScheltensAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0002-1046-6408
Thomas GasserCenter of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Patrick F ChinneryDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Bernhard HemmerDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Martijn A HuismanAmsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Juan TroncosoDepartment of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.
Fermin MorenoCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Ellen A NohrResearch Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark.
Peter HeutinkGerman Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany.
Pascual Sánchez-JuanCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Danielle PosthumaDepartment of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group
Jordi ClarimónCentro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Kaare ChristensenThe Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Nilüfer Ertekin-TanerDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Sonja W ScholzNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA.
Alfredo RamirezDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.
Agustín RuizResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
Eline SlagboomMolecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Wiesje M van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Henne HolstegeAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl.ORCID 0000-0002-7688-3087

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Harnessing Molecular Networks of Resilience for Therapeutic Discoveries in ADR01AG061796 · NIA · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2018 to 2022
$5.7M
Neuroimmune responses and therapeutics of alpha-synucleinopathies of the aging populationZIAAG000936 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2017 to 2025
$4.1M
Medical Research Council G0400713Medical Research Council G0701075Medical Research Council G0901254Medical Research Council MC_U105597119Medical Research Council MC_U123160651Medical Research Council MC_U123160657Medical Research Council MC_UU_00005/12Medical Research Council MC_UU_00015/9Medical Research Council MC_UU_00024/1Medical Research Council MC_UU_00024/9Medical Research Council MR/L501542/1Medical Research Council MR/N026004/1NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG061796NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG046139Parkinson's UK G-0907Wellcome Trust 212219/Z/18/Z
6 · The paper itself

Abstract

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.

Identifiers

PMID31955222
PMCPMC7181435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.