Evidence map›Paper›PMID 31955217›Full record

SynthesisInternational journal of colorectal disease2020

A meta-analysis of liver-first versus classical strategy for synchronous colorectal liver metastases.

Dimitrios E Magouliotis, George Tzovaras, Alexandros Diamantis, Vasiliki S Tasiopoulou, Dimitris Zacharoulis

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dimitrios E MagouliotisDivision of Surgery and Interventional Sciences, UCL, London, UK.
George TzovarasDepartment of Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Alexandros DiamantisDepartment of Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Vasiliki S TasiopoulouDepartment of Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece.
Dimitris ZacharoulisDepartment of Surgery, University of Thessaly, Biopolis, 41110, Larissa, Greece. zacharoulis@uth.gr.ORCID http://orcid.org/0000-0002-8972-064X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to compare the perioperative outcomes of liver-first (LFS) and classical (CS) strategy for the management of synchronous colorectal liver metastases (sCRLM).

methodA literature search was performed in PubMed, Scopus, and Cochrane databases, in accordance with the PRISMA guidelines. The odds ratio, weighted mean difference, and 95% confidence interval were evaluated by means of the random-effects model.

resultsTen articles met the inclusion criteria, incorporating 3656 patients. Patients in the LFS group reported increased size of sCRLM and a higher rate of major hepatectomies. This study reveals comparable overall survival and disease-free survival at 1, 3, and 5 years postoperatively between the two strategies. Moreover, the mean operative time, length of hospital stay, the incidence of severe complications, and the 30-day and 90-day mortality were similar between the two groups. The mean intraoperative blood loss was significantly increased in the LFS group.

conclusionThese outcomes suggest that both approaches are feasible and safe. Given the lack of randomized clinical trials, this meta-analysis represents the best currently available evidence. However, the results should be treated with caution given the small number of the included studies. Randomized trials comparing LFS to CS are necessary to further evaluate their outcomes.

Indexed as

Chemotherapy, AdjuvantColorectal NeoplasmsHepatectomyHumansLength of StayLiver NeoplasmsNeoplasm StagingOperative TimePostoperative ComplicationsSurvival AnalysisTime-to-TreatmentClassical strategyColorectal liver metastasesLiver-first strategyMeta-analysis

Identifiers

PMID31955217

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.