SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2020
Middle ear congenital cholesteatoma: systematic review, meta-analysis and insights on its pathogenesis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predicting residual cholesteatoma with the Potsic staging system still lacks evidence: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Use of a Flexible Ruler in Measuring the Length of Artificial Stapes During Stapedotomy Under Otoendoscopy.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- Use of Bonebridge Implant in a Child with Congenital Cholesteatoma: A Case Report.The American journal of case reports · 2025Article
- Early diagnosis and complete excision of congenital cholesteatoma in a 4-year-old boy: A case report.International journal of surgery case reports · 2025Article
- Article
- Beyond the otoscope: an imaging review of congenital cholesteatoma.Insights into imaging · 2024Review
- Congenital cholesteatoma: what radiologists need to know.Pediatric radiology · 2024Review
- Epidemiology of Congenital Cholesteatoma: Surveys of the Last 17 Years in Japan.Journal of clinical medicine · 2024Article
- [Diagnosis and treatment of congenital temporal bone cholesteatoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear.Frontiers in pharmacology · 2023Review
- Article
- Non-EPI versus Multishot EPI DWI in Cholesteatoma Detection: Correlation with Operative Findings.AJNR. American journal of neuroradiology · 2021Article
- Isolated Congenital Mastoid Cholesteatoma with no Involvement of Aditus Ad Antrum and Middle Ear.Clinical medicine insights. Case reports · 2021Review
- Surgical Guidance for Removal of Cholesteatoma Using a Multispectral 3D-Endoscope.Sensors (Basel, Switzerland) · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCongenital cholesteatoma (CC) presents as a white pearl-like lesion behind a normal tympanic membrane (TM), without a history of otorrhea, infection, perforation or previous otologic surgery. Several recent studies provided new data improving this pathology characterization. The aim of this paper is to expand the knowledge about CC and to provide new insights on its pathogenesis.
methodsThe study consisted of two main research parts: (1) systematic review and meta-analysis; (2) medical literature review englobing anatomy, histology, embryology and congenital pathology of the ear.
resultsThe search strategy identified a total of 636 papers. Seventy retrospective studies were included. A total of 1497 cases were studied and the mean age was 6.58 years, with a male-female ratio of 3:1, 34% were asymptomatic, 26% had hearing loss and 2% had facial dysfunction/paralysis. The overall estimate for antero-superior quadrant involvement was 0.70 [95% confident interval (CI) 0.64-0.76], in the postero-superior quadrant was 0.60 (95% CI 0.52-0.69), in the antero-inferior quadrant was 0.32 (95% CI 0.23-0.41), in the postero-inferior quadrant was 0.38 (95% CI 0.29-0.47), in the attic was 0.53 (95% CI 0.43-0.63) and in the mastoid was 0.33 (95% CI 0.26-0.41). More advanced Potsic stages were present in older patients. The most likely inclusion place seems to be between the pars flaccida and the upper quadrants of the pars tensa.
conclusionsDuring the last decades, a substantial improvement in CC diagnosis and management had been achieved. The presented mechanism seems to explain most of middle ear CC.
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