Evidence map›Paper›PMID 31955038›Full record

ArticleCancer epidemiology2020

Parental occupational organic dust exposure and selected childhood cancers in Denmark 1968-2016.

Julie Volk, Julia E Heck, Kjeld Schmiegelow, Johnni Hansen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  12. The Genetic Changes of Hepatoblastoma.Frontiers in oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Julie VolkDanish Cancer Society Research Centre, Copenhagen, Denmark. Electronic address: julvol@cancer.dk.
Julia E HeckUCLA Fielding School of Public Health, Department of Epidemiology, Los Angeles, CA, USA.
Kjeld SchmiegelowUniversity Hospital Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Copenhagen, Denmark.
Johnni HansenDanish Cancer Society Research Centre, Copenhagen, Denmark.
Danish Cancer Society · DKRigshospitalet · DK

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643
6 · The paper itself

Abstract

backgroundParental occupational exposures are suggested as contributing causes of childhood cancer.

methodsChildren age< = 19, born in Denmark and diagnosed with leukemia, central nervous system (CNS) cancers and likely prenatally initiated cancers [hepatoblastoma, medulloblastoma, Wilms tumor (nephroblastoma), neuroblastoma, retinoblastoma and acute lymphoid leukemia] n = 4268 were identified using Danish registries. We randomly selected twenty-five controls per case matched on birth year and sex. Parents and their employment histories were extracted from nationwide registries. We examined occupational dust exposures perinatally and postnatally in both parents. Odds ratios (ORs) and 95 % confidence intervals (95 % CI) were estimated using conditional logistic regression.

resultsMaternal wood dust exposure from birth to diagnosis was associated with increased risks of leukemia (OR 1.44, 95 % CI 1.08-1.94) and acute myeloid leukemia (OR 2.14, 95 % CI 1.13-4.03); exposure to paper dust was associated with CNS cancer (OR 2.28, 95 % CI 1.22-4.2).. Paternal exposure to wood dust was associated with astrocytoma in both periods (OR 1.43, 95 % CI 1.05-1.96 and 1.42, 1.09-1.86, respectively) and CNS cancer (OR 1.24, 95 % CI 1.00-1.53) in the perinatal period. The increased risk observed for potentially prenatally-initiated cancers in relation to wood was driven by ORs for neuroblastoma (1.54, 95 % CI 1.03-2.29) and hepatoblastoma (2.41, 95 % CI 0.99-5.88). An OR of 2.58 (95 % CI 1.10-6.05) for CNS cancer was associated with both parents working in textile industries postnatally.

conclusionThe study suggests that parental exposure to wood dust may increase risk of specific childhood cancers.

Indexed as

DustRegistriesAdolescentAdultCase-Control StudiesCentral Nervous System NeoplasmsChildChild, PreschoolDenmarkFemaleHumansInfantLeukemia, Myeloid, AcuteMaleNeoplasmsNeuroblastomaDustCase-control studyChildhood cancerParental occupational exposure

Identifiers

PMID31955038
PMCPMC7737883
OpenAlexW3000579381

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.