Evidence map›Paper›PMID 31954962›Full record

ReviewCurrent opinion in immunology2020

Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis.

Benyamin Rosental, Tal Raveh, Ayelet Voskoboynik, Irving L Weissman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. PervasivebioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022
    Article
  10. Noninvasive Intravascular Microtransfusion in Colonial Tunicates.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Marine drugs · 2021
    Review
  12. Review
  13. Article
  14. Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Benyamin RosentalBen Gurion University of the Negev, The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Regenerative Medicine and Stem Cell Research Center, P.O.B. 653 Beer-Sheva, Israel. Electronic address: rosentab@post.bgu.ac.il.
Tal RavehInstitute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, CA, USA.
Ayelet VoskoboynikInstitute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, CA, USA; Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA; Chan Zuckerberg Biohub, San Francisco CA 94158, USA. Electronic address: ayeletv@stanford.edu.
Irving L WeissmanInstitute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research, Stanford University School of Medicine, CA, USA; Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA; Chan Zuckerberg Biohub, San Francisco CA 94158, USA. Electronic address: irv@stanford.edu.
California Institute for Regenerative Medicine · USBen-Gurion University of the Negev · IL

Funding

Genes, cells, and pathways that regulate urochordate allogeneic stem cell competition and their mammalian homologuesR01GM100315 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2012 to 2019
$2.8M
Cellular and molecular mechanisms of aging and regeneration in colonial chordateR01AG037968 · NIA · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2010 to 2014
$1.5M
Molecular Characterization of Predatory Stem Cells in a Chimeric ProtochordateR56AI089968 · NIAID · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2010 to 2010
$400k
NIAID NIH HHS R56 AI089968NIA NIH HHS R01 AG037968NIGMS NIH HHS R01 GM100315
6 · The paper itself

Abstract

Evolution and selection have shaped diverse immune systems throughout phylogeny, the vast majority of which remain unexplored. Botryllus schlosseri is a colonial tunicate, a sister group to vertebrates, that develops as a chordate, then metamorphoses to an asexually reproductive invertebrate that every week makes the same body plan from budded stem cells. Genetically distinct B. schlosseri colonies can fuse to form a chimera, or reject each other based on allogeneic recognition. In chimeras, circulating germline and somatic stem cells participate in development; stem cells compete in all individuals in the fused colonies, with rejection preventing germline parasitism. Here we review the isolation and characterization of B. schlosseri hematopoietic stem cells (HSC) and their niches, and the role of the immune effector cells in allorecognition.

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsClonal HematopoiesisHematopoietic Stem CellsPhylogenyTransplantation ConditioningUrochordata

Identifiers

PMID31954962
PMCPMC7136747
OpenAlexW2999463932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.