Evidence map›Paper›PMID 31954874›Full record

ReviewExperimental gerontology2020

Kynurenine pathway, NAD

Raul Castro-Portuguez, George L Sutphin

Open access · greenAbstract readReview
In one paragraph

Review in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 3 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 3 syntheses or guidelines pooled it, 274 citations in OpenAlex.

  1. A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Pooled it
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  13. Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026
    Review
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Raul Castro-PortuguezCancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, 85721, AZ, USA.
George L SutphinCancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, 85721, AZ, USA; Department of Molecular and Cellular Biology, University of Arizona, Tucson, 85721, AZ, USA. Electronic address: sutphin@email.arizona.edu.
University of Arizona · US

Funding

Defining the genetic architecture of multi-stress responseR35GM133588 · NIGMS · UNIVERSITY OF ARIZONA · PI George Lewis Sutphin · 2019 to 2026
$3.0M
NIGMS NIH HHS R35 GM133588
6 · The paper itself

Abstract

Aging is characterized by a progressive decline in the normal physiological functions of an organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD

Indexed as

LongevityMetabolic Networks and PathwaysAgingAnimalsBrainHumansKynurenineMiceMitochondriaMitophagyNADNeurodegenerative DiseasesOxidation-ReductionOxidative StressTryptophanKynurenineNADTryptophanKynurenine pathwayMitochondriaNADOxidative stressTryptophan

Identifiers

PMID31954874
PMCPMC7053056
OpenAlexW2999612700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.