ReviewComparative biochemistry and physiology. Part A, Molecular & integrative physiology2020
A dose of experimental hormesis: When mild stress protects and improves animal performance.
Review in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 174 citations in OpenAlex.
- Herbivore Immunity Exhibits a Biphasic Relationship with Plant Defense Toxin Concentrations.Journal of chemical ecology · 2026Article
- Dimethyl itaconate attenuates dextran sulfate sodium-induced ulcerative colitis in BALB/c mice: investigations on the TXNIP/NLRP3 inflammasome signaling pathway.Inflammopharmacology · 2026Article
- All-Trans Retinoic Acid and Curcumin Exhibit Hormesis or Synergistic Anticancer Effects in U87 Glioblastoma Cells: Defining the Proteome Accompanying Synergism.International journal of molecular sciences · 2026Article
- The Fly Maggot Antioxidant Peptide (FMP) Alleviates Oxidative Damage in the Intestines of Weaned Piglets by Enhancing Mitochondrial Autophagy Through Activation of the Nrf2 Signaling Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Review
- When is RCH not RCH? Rapid cold hardening has steep temperature thresholds inducing high survival but low fertility resilience to cold stress.The Journal of experimental biology · 2026Article
- Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects).International journal of molecular sciences · 2026Review
- Dietary Glyphosate Exposure Disrupts Hepatic and Reproductive Function in Female Zebrafish at Regulatory Safe Levels.Toxics · 2026Article
- Stress-Induced Cross-Protection and Combined Stress Responses in Extremotolerant Black Yeasts.Journal of fungi (Basel, Switzerland) · 2026Article
- Distinct endothelial gene responses to acute exercise in skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2025Article
- Dietary shifts in infected mosquitoes suggest a form of self-medication despite benefits in uninfected individuals.Proceedings. Biological sciences · 2025Article
- Honey bees are resilient to the long-term presence of alcohol in their diet.Ecotoxicology (London, England) · 2025Article
- Exploring Biological Evidence of Radioprotective Effects and Critical Oxygen Thresholds inInsects · 2025Article
- Hypoxia extends lifespan but does not alter telomere length or oxidative stress in a solitary bee (Megachile rotundata).The Journal of experimental biology · 2025Article
- Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways.International journal of molecular sciences · 2025Review
- Article
- Glyphosate effects on growth and biofilm formation in bee gut symbionts and diverse associated bacteria.Applied and environmental microbiology · 2024Article
- A new biostimulant derived from soybean by-products enhances plant tolerance to abiotic stress triggered by ozone.BMC plant biology · 2024Article
- Current advances and future trends of hormesis in disease.npj aging · 2024Review
- Different mechanisms of X-ray irradiation-induced male and female sterility in Aedes aegypti.BMC biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The adaptive response characterized by a biphasic curve is known as hormesis. In a hormesis framework, exposure to low doses leads to protective and beneficial responses while exposures to high doses are damaging and detrimental. Comparative physiologists have studied hormesis for over a century, but our understanding of hormesis is fragmented due to rifts in consensus and taxonomic-specific terminology. Hormesis has been and is currently known by multiple names; preconditioning, conditioning, pretreatment, cross tolerance, adaptive homeostasis, and rapid stress hardening (mostly low temperature: rapid cold hardening). These are the most common names used to describe adaptive stress responses in animals. These responses are mechanistically similar, while having stress-specific responses, but they all can fall under the umbrella of hormesis. Here we review how hormesis studies have revealed animal performance benefits in response to changes in oxygen, temperature, ionizing radiation, heavy metals, pesticides, dehydration, gravity, and crowding. And how almost universally, hormetic responses are characterized by increases in performance that include either increases in reproduction, longevity, or both. And while the field can benefit from additional mechanistic work, we know that many of these responses are rooted in increases of antioxidants and oxidative stress protective mechanisms; including heat shock proteins. There is a clear, yet not fully elucidated, overlap between hormesis and the preparation for oxidative stress theory; which predicts part of the responses associated with hormesis. We discuss this, and the need for additional work into animal hormetic effects particularly focusing on the cost of hormesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.