Evidence map›Paper›PMID 31954511›Full record

ReviewTrends in genetics : TIG2020

From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection.

Hussein A Hejase, Noah Dukler, Adam Siepel

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
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  9. Review
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  12. A general and efficient representation of ancestral recombination graphs.bioRxiv : the preprint server for biology · 2024
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  14. Article
  15. Review
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  17. Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hussein A HejaseSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: hijazi@cshl.edu.
Noah DuklerSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Adam SiepelSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Funding

Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional RegulationR35GM127070 · NIGMS · COLD SPRING HARBOR LABORATORY · PI Adam Charles Siepel · 2018 to 2026
$4.7M
Evolution of Chromatin Architecture and Transcriptional Regulation in MammalsR01HG010346 · NHGRI · CORNELL UNIVERSITY · PI DANKO, CHARLES GRAHE, SIEPEL, ADAM CHARLES · 2019 to 2022
$2.7M
NHGRI NIH HHS R01 HG010346NIGMS NIH HHS R35 GM127070
6 · The paper itself

Abstract

Methods to detect signals of natural selection from genomic data have traditionally emphasized the use of simple summary statistics. Here, we review a new generation of methods that consider combinations of conventional summary statistics and/or richer features derived from inferred gene trees and ancestral recombination graphs (ARGs). We also review recent advances in methods for population genetic simulation and ARG reconstruction. Finally, we describe opportunities for future work on a variety of related topics, including the genetics of speciation, estimation of selection coefficients, and inference of selection on polygenic traits. Together, these emerging methods offer promising new directions in the study of natural selection.

Indexed as

Evolution, MolecularAlgorithmsComputer SimulationGenetics, PopulationModels, GeneticMultifactorial InheritancePhylogenyRecombination, GeneticSelection, Geneticancestral recombination graphmachine learningsimulation

Identifiers

PMID31954511
PMCPMC7177178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.