ArticleJournal of hepatology2020
Physical activity compared to adiposity and risk of liver-related mortality: Results from two prospective, nationwide cohorts.
Article in Journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).Obesity facts · 2024Guideline
- Physical Activity and Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2023Pooled it
- Associations between Physical Activity and Liver Cancer Risks and Mortality: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Change lifestyle modification plan/transtheoretical model in non-alcoholic simple fatty liver disease: a pilot randomized study.BMC gastroenterology · 2022Trial
- Prophylactic Effects of Dietary Patterns and Indexes, Nutrition and Lifestyle on Hepatocellular Carcinoma.Annals of surgical oncology · 2026Review
- Exercise as a Multisystem Adjunct for Alcohol-Associated Liver Disease: Inflammatory Mechanisms, Muscle-Liver Crosstalk, and Translational Gaps.Metabolites · 2026Review
- Independent and joint associations of fatty liver index and physical activity with mortality in adults with hypertension: a nationwide cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The effect of air pollution on chronic liver disease and the modifying effect of physical activity: a nationwide study from CHARLS.BMC public health · 2025Article
- Review
- Risks of liver cirrhosis, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes in Taiwan.World journal of diabetes · 2025Article
- Article
- Physical activity, diet, and social determinants of health associate with health related quality of life and fibrosis in MASLD.Scientific reports · 2025Article
- The role of obesity in mortality from digestive diseases in UK Biobank.Scientific reports · 2024Article
- A survey questionnaire evaluating physical activity patterns and determinants in patients with chronic liver disease.Journal of gastroenterology · 2024Article
- Trends in liver cancer mortality in China from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019.BMJ open · 2023Article
- Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Association of Physical Activity Intensity with All-Cause Mortality in Cancer Survivors: A National Prospective Cohort Study.Cancers · 2022Article
- Review
- Review
- Gut microbiome in gastrointestinal cancer: a friend or foe?International journal of biological sciences · 2022Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
Abstract
BACKGROUND &
aimsObesity in adulthood has been associated with increased risk of liver-related mortality. Whether higher levels of physical activity counteract the excess risk conferred by obesity remains unknown. We simultaneously evaluated the long-term impact of physical activity and adiposity on liver-related mortality, within 2 nationwide populations.
methodsWe conducted a prospective cohort study of 77,238 women and 48,026 men, with detailed, validated assessments of weekly physical activity (metabolic equivalent task [MET]-hours]), adiposity (body mass index [BMI], waist circumference), and diet, alcohol use and clinical comorbidities, biennially from 1986 through 2012. Using Cox proportional hazards regression models, we calculated multivariable-adjusted hazard ratios (aHRs) and 95% CIs for liver-related mortality, including death from hepatocellular carcinoma (HCC) and other complications of cirrhosis.
resultsOver 1,856,226 person-years, we recorded 295 liver-related deaths (108 HCC; 187 cirrhosis). Risk of liver-related mortality increased monotonically with higher BMI during adulthood (p
conclusionsIn 2 prospective, nationwide cohorts, both excess adiposity and reduced physical activity were significant predictors of liver-related mortality. Achieving higher physical activity levels counteracted the excess liver-related risks associated with obesity. LAY SUMMARY: This is the first large, prospective cohort study to simultaneously evaluate the impact of obesity and physical activity on the long-term risk of liver-related mortality in 2 nationwide populations of American men and women. The study demonstrated that obesity predicted significantly increased risk of liver-related mortality, while physical activity predicted significantly lower risk of liver-related mortality. Importantly, the excess risk of liver-related mortality observed with obesity was no longer statistically significant among adults who engaged in the equivalent of average-pace walking for 3 hours or more, per week.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.