Evidence map›Paper›PMID 31954106›Full record

ArticleBiochimica et biophysica acta. Biomembranes2020

The antioxidant vitamin E as a membrane raft modulator: Tocopherols do not abolish lipid domains.

Mitchell DiPasquale, Michael H L Nguyen, Brett W Rickeard, Nicole Cesca, Christopher Tannous, Stuart R Castillo, John Katsaras, Elizabeth G Kelley, Frederick A Heberle, Drew Marquardt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Mitchell DiPasqualeDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
Michael H L NguyenDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
Brett W RickeardDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
Nicole CescaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
Christopher TannousDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
Stuart R CastilloDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada.
John KatsarasNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA; Joint Institute for Neutron Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA; Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996, USA.
Elizabeth G KelleyNIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Frederick A HeberleDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.
Drew MarquardtDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario,Canada; Department of Physics, University of Windsor, Windsor, Ontario, Canada. Electronic address: drew.marquardt@uwindsor.ca.
University of Windsor · CANational Institute of Standards and Technology · USOak Ridge National Laboratory · USUniversity of Tennessee at Knoxville · US

Funding

Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now marketed as a lipid raft destabilizing anti-cancer agent, in addition to its antioxidant behaviour. Here, we studied the influence of vitamin E and some of its vitamers on membrane raft stability using phase separating unilamellar lipid vesicles in conjunction with small-angle scattering techniques and fluorescence microscopy. We find that lipid phase behaviour remains unperturbed well beyond physiological concentrations of vitamin E (up to a mole fraction of 0.10). Our results are consistent with a proposed line active role of vitamin E at the domain boundary. We discuss the implications of these findings as they pertain to lipid raft modification in native membranes, and propose a new hypothesis for the antioxidant mechanism of vitamin E.

Indexed as

AntioxidantsCell MembraneHumansLipid MetabolismMembrane MicrodomainsMicroscopy, FluorescenceTocopherolsUnilamellar LiposomesVitamin EAntioxidantsTocopherolsUnilamellar LiposomesVitamin ELipid bilayerLipid raftsSmall-angle neutron scatteringVitamin Eα -Tocopherolγ -Tocopherol

Identifiers

PMID31954106
PMCPMC10443432
OpenAlexW2999731762

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.