Evidence map›Paper›PMID 31953884›Full record

ArticlePediatric diabetes2021

Clinical profile at diagnosis with youth-onset type 1 and type 2 diabetes in two pediatric diabetes registries: SEARCH (United States) and YDR (India).

Christine W Hockett, Pradeep A Praveen, Toan C Ong, Anandakumar Amutha, Scott P Isom, Elizabeth T Jensen, Ralph B D'Agostino, Richard F Hamman, Elizabeth J Mayer-Davis, Jean M Lawrence and 5 more

Abstract readComparative Study
In one paragraph

Article in Pediatric diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. ICMR-MDRF Diabetes Biosamples: Cohort profile.The Indian journal of medical research · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christine W HockettLifecourse Epidemiology of Adiposity and Diabetes Center, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.ORCID 0000-0002-1665-6763
Pradeep A PraveenDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Toan C OngDepartment of Pediatrics, University of Colorado, Aurora, Colorado.
Anandakumar AmuthaDr. Mohan's Diabetes Specialties Centre and Madras Diabetes Research Foundation, Chennai, India.
Scott P IsomDepartment of Biostatistics and Bioinformatics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Elizabeth T JensenDepartment of Epidemiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Ralph B D'AgostinoDepartment of Biostatistics and Bioinformatics, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Richard F HammanLifecourse Epidemiology of Adiposity and Diabetes Center, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.
Elizabeth J Mayer-DavisDepartment of Nutrition and Medicine, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0003-3858-0517
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, Washington.ORCID 0000-0001-9074-7770
Michael G KahnDepartment of Pediatrics, University of Colorado, Aurora, Colorado.
Viswanathan MohanDr. Mohan's Diabetes Specialties Centre and Madras Diabetes Research Foundation, Chennai, India.ORCID 0000-0001-5038-6210
Nikhil TandonDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID 0000-0003-4604-1986
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes Center, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado.ORCID 0000-0001-9514-8929

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
SEARCH for Diabetes in Youth 2: South Carolina CenterU01DP000254 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2005 to 2009
$3.5M
SEARCH for Diabetes in Youth 3: Washington Site, Part BU18DP002710 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2010 to 2014
$3.2M
ACL HHS U18DP006131ACL HHS U18DP006133ACL HHS U18DP006134ACL HHS U18DP006136ACL HHS U18DP006138ACL HHS U18DP006139HSRD VA HIR 10-001NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001450NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006138NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R21 DK105869NIDDK NIH HHS R21DK105869-02
6 · The paper itself

Abstract

backgroundOver the last decades, diabetes in youth has increased in both India and the United States, along with the burden of long-term complications and healthcare costs. However, there are limited standardized population-based data in contemporary youth cohorts for comparison of clinical and demographic characteristics of diabetes for both type 1 (T1D) and type 2 (T2D).

methodsIn partnership, we harmonized demographic and clinical data from the SEARCH for Diabetes in Youth (SEARCH) registry in the United States and the Registry of People with Diabetes with Youth Age at Onset (YDR) in India to the structure and terminology of the Observational Medical Outcomes Partnership Common Data Model. Data were from youth with T1D and T2D, aged <20 years and newly diagnosed between 2006 and 2010. We compared key characteristics across registries using χ

resultsIn total, there were 9650 youth with T1D and 2406 youth with T2D from 2006 to 2012. SEARCH youth were diagnosed at younger ages than YDR youth for T1D and T2D (10.0 vs 10.5 years, P < .001 and 14.7 vs 16.1 years, P < .001, respectively). For T2D, SEARCH had a higher proportion of females and significantly lower proportion of youth of high socioeconomic status compared to YDR. For T1D and T2D, SEARCH youth had higher BMI, lower blood pressure, and lower A1c compared to YDR youth.

conclusionsThese data offer insights into the demographic and clinical characteristics of diabetes in youth across the two countries. Further research is needed to better understand why these differences exist.

Indexed as

AdolescentAge of OnsetChildDemographyDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansIndiaMaleRegistriesUnited Statesdata harmonizationearly onset type 2 diabetesIndiaregistrytype 1 diabetesUnited States

Identifiers

PMID31953884
PMCPMC7785282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.