Evidence map›Paper›PMID 31953741›Full record

ArticleNeurochemical research2020

Extracellular Vesicles Derived from Epidural Fat-Mesenchymal Stem Cells Attenuate NLRP3 Inflammasome Activation and Improve Functional Recovery After Spinal Cord Injury.

Jiang-Hu Huang, Chun-Hui Fu, Yang Xu, Xiao-Ming Yin, Yong Cao, Fei-Yue Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Rewiring the Spine-Cutting-Edge Stem Cell Therapies for Spinal Cord Repair.International journal of molecular sciences · 2025
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  13. Article
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  16. Clinical applications of stem cell-derived exosomes.Signal transduction and targeted therapy · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jiang-Hu HuangShengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, People's Republic of China.
Chun-Hui FuFuzhou Maixin Biotech. Co., Ltd, Fuzhou, 350001, People's Republic of China.
Yang XuShengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, People's Republic of China.
Xiao-Ming YinShengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, People's Republic of China.
Yong CaoDepartment of Spine Surgery, Xiangya Hospital of Central South University, Changsha, 410008, People's Republic of China. caoyong1912@163.com.
Fei-Yue LinShengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, People's Republic of China. feiyuelinsl@sina.com.
Fujian Medical University · CNCentral South University · CNFujian Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a devastating event which caused high mortality and morbidity. Recently, nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome has been showed to act a critical t role in the secondly injury phase of SCI. In current study, we aimed to investigate the effect and underlying molecular mechanisms of extracellular vesicles derived from epidural fat (EF)- mesenchymal stem cells (MSCs) for the treatment of SCI. Ninety-six Sprague-Dawley rats were used for current study and randomly divided into four groups: sham group, SCI group, SCI + Saline group, SCI + Extracellular vesicles group. Basso-Beattie-Bresnahan (BBB) scores was applied to evaluate the neurological functional recovery. Cresyl violet-stained was conducted evaluate the protective effect of EF-MSCs-Extracellular vesicles on lesion volume after SCI. ELISA, immunohistochemistry assay, TUNEL assay and western blotting were conducted to investigate the underlying molecular mechanisms. Our results demonstrated that the administration of EF-MSCs-Extracellular vesicles via tail vein injection improved neurological functional recovery and reduced the lesion volume after SCI. And systemic administration of EF-MSCs-Extracellular vesicles significantly inhibited NLRP3 inflammasome activation and reduced the expression of inflammatory cytokines. Additionally, the expression levels of proapoptotic protein Bax was decreased and antiapoptotic Bcl-2 was upregulated with the treatment of EF-MSCs-Extracellular vesicles after SCI. In summary, in current study, we demonstrated for the first time that the EF-MSCs-Extracellular vesicles can improve neurological functional recovery after SCI, and the underlying molecular mechanisms may partly through the inhibition of NLRP3 inflammasome activation.

Indexed as

Extracellular VesiclesAdipose TissueAnimalsApoptosisCytokinesEpidural SpaceHumansInflammasomesMaleMesenchymal Stem CellsNLR Family, Pyrin Domain-Containing 3 ProteinRats, Sprague-DawleyRecovery of FunctionSpinal CordSpinal Cord InjuriesCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinApoptosisEpidural fat-mesenchymal stem cells extracellular vesicles (EF-MSCs-extracellular vesicles)Functional recoveryNLRP3 inflammasomeSpinal cord injury (SCI)

Identifiers

PMID31953741
OpenAlexW3000487378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.