Evidence map›Paper›PMID 31953701›Full record

ArticleCytotechnology2020

MicroRNA-125a-3p participates in odontoblastic differentiation of dental pulp stem cells by targeting Fyn.

Jihua Wang, Ya Zheng, Bingbing Bai, Yihua Song, Ke Zheng, Jinwen Xiao, Yi Liang, Liuliu Bao, Qiao Zhou, Lujun Ji and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  15. NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jihua WangDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Ya ZhengResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Bingbing BaiDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Yihua SongDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Ke ZhengDepartment of Stomatology, Wuxi No. 2 People Hospital, Wuxi, 214000, China.
Jinwen XiaoDepartment of Stomatology, People's Hospital of Haimen, Nantong, China.
Yi LiangDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Liuliu BaoDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Qiao ZhouDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Lujun JiDepartment of Stomatology, Tongzhou People's Hospital, Taizhou, 225300, China. jilujun678@sina.com.
Xingmei FengDepartment of Stomatology, Affiliated Hospital of Nantong University, Nantong, 226001, China. Xingmeifeng@ntu.edu.cn.ORCID http://orcid.org/0000-0001-8046-3336
Nantong University · CNWuxi No.2 People's Hospital · CN

Funding

Nantong Science and Technology Project MS22016043Science and technology Project of Nantong City MS1201712-2Six Talent Peaks Project in Jiangsu Province No. 2016-WSN-103
6 · The paper itself

Abstract

Fyn is a member of the protein tyrosine kinase family and its overexpression is associated with various types of inflammation. MicroRNAs can regulate the expression of target genes and play an important role in varied physiological and pathological processes. Based on the important role of Fyn and microRNA-125a-3p (miR-125a-3p) in inflammation, and combined with the bioinformatics studies, we performed in this study and chose miR-125a-3p as the focus of our research. During the progression of inflammation, we found that the expression of miR-125a-3p was decreased while the expression of Fyn was up-regulated. Fyn formed a complex with Neuropilin-1, which inhibited odontoblastic differentiation and expanded inflammatory responses through nuclear factor-κB signal pathways in dental pulp stem cells (DPSCs). These findings suggested that miR-125a-3p plays an important role in odontoblastic differentiation of DPSCs by targeting Fyn, implying its therapeutic potential in dental caries.

Indexed as

Dental cariesDental pulp stem cells (DPSCs)FynMicroRNA-125a-3pOdontoblastic differentiation

Identifiers

PMID31953701
PMCPMC7002700
OpenAlexW2999924952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.