ArticleJournal of neuro-oncology2020
Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma.
Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.Neuro-oncology advances · 2026Review
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Patient-Centered Management of Brain Tumor-Related Epilepsy.Current neurology and neuroscience reports · 2024Review
- Intratumoral calcification: not only a diagnostic but also a prognostic indicator in oligodendrogliomas.European radiology · 2024Article
- Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life.Journal of cancer survivorship : research and practice · 2024Article
- The relationship between pathological brain activity and functional network connectivity in glioma patients.Journal of neuro-oncology · 2024Article
- Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management.Neuro-oncology · 2024Review
- Progress in cancer neuroscience.MedComm · 2023Review
- Multiscale network neuroscience in neuro-oncology: How tumors, brain networks, and behavior connect across scales.Neuro-oncology practice · 2023Review
- The neuroscience of cancer.Nature · 2023Review
- Considerations for modelling diffuse high-grade gliomas and developing clinically relevant therapies.Cancer metastasis reviews · 2023Review
- Article
- Regional healthy brain activity, glioma occurrence and symptomatology.Brain : a journal of neurology · 2022Article
- Neuron-Glial Interactions in Health and Brain Cancer.Advanced biology · 2022Review
- Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma.Journal of neuro-oncology · 2022Observational
- Non-invasively measured brain activity and radiological progression in diffuse glioma.Scientific reports · 2021Observational
- The relationship between deviant brain activity and executive functioning in glioma patients.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
introductionProgression-free survival (PFS) in glioma patients varies widely, even when stratifying for known predictors (i.e. age, molecular tumor subtype, presence of epilepsy, tumor grade and Karnofsky performance status). Neuronal activity has been shown to accelerate tumor growth in an animal model, suggesting that brain activity may be valuable as a PFS predictor. We investigated whether postoperative oscillatory brain activity, assessed by resting-state magnetoencephalography is of additional value when predicting PFS in glioma patients.
methodsWe included 27 patients with grade II-IV gliomas. Each patient's oscillatory brain activity was estimated by calculating broadband power (0.5-48 Hz) in 56 epochs of 3.27 s and averaged over 78 cortical regions of the Automated Anatomical Labeling atlas. Cox proportional hazard analysis was performed to test the predictive value of broadband power towards PFS, adjusting for known predictors by backward elimination.
resultsHigher broadband power predicted shorter PFS after adjusting for known prognostic factors (n = 27; HR 2.56 (95% confidence interval (CI) 1.15-5.70); p = 0.022). Post-hoc univariate analysis showed that higher broadband power also predicted shorter overall survival (OS; n = 38; HR 1.88 (95% CI 1.00-3.54); p = 0.038).
conclusionsOur findings suggest that postoperative broadband power is of additional value in predicting PFS beyond already known predictors.
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