Evidence map›Paper›PMID 31953443›Full record

ArticleScientific reports2020

Background calcium induced by subthreshold depolarization modifies homosynaptic facilitation at a synapse in Aplysia.

Bjoern Ch Ludwar, Klaudiusz R Weiss, Elizabeth C Cropper

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Bjoern Ch LudwarDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Klaudiusz R WeissDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Elizabeth C CropperDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. elizabeth.cropper@gmail.com.
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · US

Funding

Neural Basis of Behavioral ArousalR01NS066587 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CROPPER, ELIZABETH C · 2009 to 2023
$5.2M
Neural Basis of Behavioral FlexibilityR01NS070583 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CROPPER, ELIZABETH C, WEISS, KLAUDIUSZ ROBERT · 2010 to 2020
$3.6M
NINDS NIH HHS R01 NS066587NINDS NIH HHS R01 NS070583
6 · The paper itself

Abstract

Some synapses show two forms of short-term plasticity, homosynaptic facilitation, and a plasticity in which the efficacy of transmission is modified by subthreshold changes in the holding potential of the presynaptic neuron. In a previous study we demonstrated a further interactive effect. We showed that depolarizing changes in the presynaptic holding potential can increase the rate at which facilitation occurs. These experiments studied synaptic transmission between an Aplysia sensory neuron (B21) and its postsynaptic follower, the motor neuron (B8). We have also shown that subthreshold depolarizations of B21 produce widespread increases in its [Ca

Indexed as

AnimalsAplysiaCalciumMotor NeuronsSensory Receptor CellsSynapsesCalcium

Identifiers

PMID31953443
PMCPMC6969054
OpenAlexW3000480252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.