ArticleScientific reports2020
Early-Onset Osteoarthritis originates at the chondrocyte level in Hip Dysplasia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Childhood growth associated with hip shapes at skeletal maturity: the Bergen Hip Cohort Study.BMC musculoskeletal disorders · 2025Trial
- Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by Sex.bioRxiv : the preprint server for biology · 2026Article
- Total hip arthroplasty outcomes for developmental dysplasia of the hip versus primary osteoarthritis: Older age increases medical, not surgical complications.Journal of clinical orthopaedics and trauma · 2025Article
- Evaluation of Serum and Urine Biomarker Panels for Developmental Dysplasia of the Hip Prior to Onset of Secondary Osteoarthritis.Cartilage · 2024Article
- Roles of combined femoral and acetabular anteversion in pathological changes of hip dysplasia and hip reconstructive surgery.World journal of orthopedics · 2024Article
- T2 MAPPING OF ACETABULAR CARTILAGE IN PATIENTS WITH PRIMARY OSTEOARTHRITIS AND DDH-INDUCED SECONDARY OSTEOARTHRITIS ANALYSED WITH 7 TESLA MICRO-MRI.Acta clinica Croatica · 2023Article
- Analysis of the association between the acetabular morphology and femoral head in children aged 0-3 years with developmental hip dysplasia.Frontiers in pediatrics · 2023Article
- Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing.International journal of molecular sciences · 2022Article
- Clinical and Radiological Outcomes of Revision Total Hip Arthroplasty for Patients with Prior Hartofilakidis Type C Hip Dysplasia.Orthopaedic surgery · 2022Article
- Identification of KANSL1 as a novel pathogenic gene for developmental dysplasia of the hip.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis.Scientific reports · 2022Article
- Proteomic, mechanical, and biochemical characterization of cartilage development.Acta biomaterialia · 2022Article
- Targeted treatment for osteoarthritis: drugs and delivery system.Drug delivery · 2021Review
- What are the significant factors affecting pain in patients with Hartofilakidis type Ι developmental dysplasia of the hip?Journal of orthopaedic surgery and research · 2021Article
- Analysis of Factors Affecting Early Functional Recovery of Bernese Periacetabular Osteotomy.Orthopaedic surgery · 2021Article
- Joint disease-specificity at the regulatory base-pair level.Nature communications · 2021Article
- Confocal scanning of intervertebral disc cells in 3D: Inside alginate beads and in native microenvironment.JOR spine · 2020Article
- Treatment of unstable hips with the Tübingen splint in early postnatal period: radiological mid-term results of 75 hips with mean follow-up of 5.5 years.Journal of children's orthopaedics · 2020Article
- Is Hip Arthroscopy an Adequate Therapy for the Borderline Dysplastic Hip? Correlation Between Radiologic Findings and Clinical Outcomes.Orthopaedic journal of sports medicine · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Subjects with developmental dysplasia of the hip (DDH) often show early-onset osteoarthritis (OA); however, the molecular mechanisms underlying this pathology are not known. We investigated whether cellular changes in chondrocytes from OA cartilage can be detected in chondrocytes from DDH cartilage before histological manifestations of degeneration. We characterized undamaged and damaged articular cartilage from 22 participants having hip replacement surgery with and without DDH (9 DDH-OA, 12 OA-only, one femoral fracture). Tissue immunostaining revealed changes in damaged OA-only cartilage that was also found in undamaged DDH-OA cartilage. Chondrocytes in situ from both groups show: (i) thicker fibers of vimentin intermediate filaments, (ii) clusters of integrin α
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.