Evidence map›Paper›PMID 31953351›Full record

Trial reportJournal of immunology (Baltimore, Md. : 1950)2020

Helminth Coinfection Alters Monocyte Activation, Polarization, and Function in Latent

Anuradha Rajamanickam, Saravanan Munisankar, Chandrakumar Dolla, Pradeep A Menon, Thomas B Nutman, Subash Babu

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Impact ofOpen forum infectious diseases · 2025
    Article
  4. Transmission-Blocking Vaccines against Schistosomiasis Japonica.International journal of molecular sciences · 2024
    Review
  5. Macrophage-derived extracellular vesicles fromFrontiers in immunology · 2024
    Article
  6. Article
  7. Prevalence and Clinical Relevance ofOpen journal of epidemiology · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anuradha RajamanickamNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai 600031, India.ORCID 0000-0002-8143-5502
Saravanan MunisankarNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai 600031, India.
Chandrakumar DollaNational Institute for Research in Tuberculosis, Chennai 600031, India; and.
Pradeep A MenonNational Institute for Research in Tuberculosis, Chennai 600031, India; and.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-6887-4941
Subash BabuNational Institutes of Health-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai 600031, India; sbabu@mail.nih.gov.ORCID 0000-0001-9783-8042
International Centers for Excellence in Research · INNational Institute of Research in Tuberculosis · INNational Institutes of Health · US

Funding

Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic InfectionZIAAI000197 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$23.4M
India International Center for Excellence in ResearchZIAAI001065 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$19.0M
Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Helminth infections are known to influence T and B cell responses in latent tuberculosis infection (LTBI). Whether helminth infections also modulate monocyte responses in helminth-LTBI coinfection has not been fully explored. To this end, we examined the activation, polarization, and function of human monocytes isolated from individuals with LTBI with (

Indexed as

CoinfectionMonocytesStrongyloidiasisAdultAnimalsAntigens, CDCytokinesFemaleHumansLatent TuberculosisMaleMycobacterium tuberculosisStrongyloides stercoralisAntigens, CDCytokines

Identifiers

PMID31953351
PMCPMC7033029
OpenAlexW2999876583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.