ArticleThe Journal of biological chemistry2020
The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Understanding Ion Channel Gating Mechanisms by Molecular Dynamics Simulations.Advances in experimental medicine and biology · 2026Review
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- A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.Nature communications · 2024Article
- Potassium channels in animal models of post-traumatic stress disorder: mechanistic and therapeutic implications.Frontiers in cellular neuroscience · 2024Article
- Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.Frontiers in physiology · 2024Review
- Identification of Potential Modulators of a Pathogenic G Protein-Gated Inwardly Rectifying KMolecules (Basel, Switzerland) · 2023Article
- PI(4,5)P2 regulates the gating of NaV1.4 channels.The Journal of general physiology · 2023Article
- Mechanism of PKCε regulation of cardiac GIRK channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- PI(4,5)PAdvances in experimental medicine and biology · 2023Article
- Hypoxia inhibits the cardiaciScience · 2022Article
- Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism.International journal of molecular sciences · 2022Article
- Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022Review
- A novel small-molecule selective activator of homomeric GIRK4 channels.The Journal of biological chemistry · 2022Article
- G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs).Pharmacology & therapeutics · 2022Review
- AsKC11, a Kunitz Peptide fromMarine drugs · 2022Article
- Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying KMolecular pharmacology · 2021Article
- Discovery, synthesis and biological characterization of a series ofRSC medicinal chemistry · 2021Article
- Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology.American journal of physiology. Cell physiology · 2021Review
- Advances in Targeting GIRK Channels in Disease.Trends in pharmacological sciences · 2021Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Yu XuDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Lucas CantwellDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Andrei I MoloshDepartment of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Leigh D PlantDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Dimitris GazgalisDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Stephanie D FitzDepartment of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Erik T DustrudeDepartment of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Yuchen YangDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Takeharu KawanoDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Sumanta GaraiDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.
Sami F NoujaimMolecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612.
Anantha ShekharDepartment of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202. Electronic address: ashekhar@iu.edu.
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115. Electronic address: d.logothetis@northeastern.edu.
Ganesh A ThakurDepartment of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115. Electronic address: g.thakur@northeastern.edu.
Northeastern University · USIndiana Clinical and Translational Sciences Institute · USUniversity of South Florida · US
Funding
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MStructural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6MNEUROBIOLOGY OF PANIC AND ANXIETY DISORDERSR01MH052619 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SHEKHAR, ANANTHA · 1996 to 2016
$5.0MSerotonin and CRF Pathways in Anxiety &HPA RegulationR01MH065702 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI LOWRY, CHRISTOPHER A, SHEKHAR, ANANTHA · 2003 to 2013
$2.8MA Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2MMolecular Mechanisms for Atrial Fibrillation in AgingR01HL129136 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2015 to 2019
$2.0MBioengineered peptibodies as antiarrhythmic therapy in atrial fibrillationR21HL138064 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2017 to 2018
$411kNCATS NIH HHS UL1 TR001108NEI NIH HHS R01 EY024717NHLBI NIH HHS R01 HL059949NHLBI NIH HHS R01 HL129136NHLBI NIH HHS R21 HL138064NIMH NIH HHS R01 MH052619NIMH NIH HHS R01 MH065702
Abstract
G-protein-gated inwardly-rectifying K
Indexed as
Allosteric RegulationAmygdalaAnimalsBehavior, AnimalBinding SitesBrainCognitionExtinction, PsychologicalFearG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHeart AtriaHEK293 CellsHumansIon Channel GatingLigandsMice, Inbred C57BLCID 56642816G Protein-Coupled Inwardly-Rectifying Potassium ChannelsLigandsPhenylurea CompoundsPhosphatidylinositol 4,5-DiphosphateProtein SubunitsPyrazolesSmall Molecule Librariesbasolateral amygdalaGIRK channelsmedicinal chemistryneurophysiologyphosphoinositidePIP2potassium channelsmall moleculespecific activator
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.