Evidence map›Paper›PMID 31953317›Full record

ArticleeNeuro

Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model.

Elizabeth A McCullagh, Shani Poleg, Nathaniel T Greene, Molly M Huntsman, Daniel J Tollin, Achim Klug

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Presynaptic CaCell reports · 2026
    Article
  3. Article
  4. Presynaptic CabioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Hearing ability of prairie voles (Microtus ochrogaster).The Journal of the Acoustical Society of America · 2024
    Article
  11. Mouse models of fragile X-related disorders.Disease models & mechanisms · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Hyperexcitability and Homeostasis in Fragile X Syndrome.Frontiers in molecular neuroscience · 2021
    Article
  17. Article
  18. Mechanisms underlying auditory processing deficits in Fragile X syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth A McCullaghDepartment of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045 Elizabeth.mccullagh@okstate.edu.ORCID 0000-0003-3779-0141
Shani PolegDepartment of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045.
Nathaniel T GreeneDepartment of Otolaryngology, University of Colorado Anschutz, Aurora, Colorado 80045.
Molly M HuntsmanDepartments of Pediatrics and Pharmaceutical Sciences, University of Colorado Anschutz, Aurora, Colorado 80045.
Daniel J TollinDepartment of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045.ORCID 0000-0001-6790-1290
Achim KlugDepartment of Physiology and Biophysics, University of Colorado Anschutz, Aurora, Colorado 80045.ORCID 0000-0002-3383-850X
University of Colorado Anschutz Medical Campus · USOklahoma State University · US

Funding

ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
The contributions of age related changes in the sound localization pathway to central hearing lossR01DC017924 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI KLUG, ACHIM, TOLLIN, DANIEL J · 2019 to 2023
$2.9M
Neuronal Transdifferention in vivo: Mechanism and PotentialR01NS086839 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2014 to 2018
$1.7M
NIDCD NIH HHS R01 DC017924NIDCD NIH HHS T32 DC012280
6 · The paper itself

Abstract

The auditory brainstem compares sound-evoked excitation and inhibition from both ears to compute sound source location and determine spatial acuity. Although alterations to the anatomy and physiology of the auditory brainstem have been demonstrated in fragile X syndrome (FXS), it is not known whether these changes cause spatial acuity deficits in FXS. To test the hypothesis that FXS-related alterations to brainstem circuits impair spatial hearing abilities, a reflexive prepulse inhibition (PPI) task, with variations in sound (gap, location, masking) as the prepulse stimulus, was used on

Indexed as

Fragile X SyndromeHearingAcoustic StimulationAnimalsFragile X Messenger Ribonucleoprotein 1MiceMice, KnockoutFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1acoustic startle responsebinaural hearingfragile X syndromeprepulse inhibitionspatial acuity

Identifiers

PMID31953317
PMCPMC7031856
OpenAlexW2999669573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.