ArticleProceedings of the National Academy of Sciences of the United States of America2020
Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024Pooled it
- From Lipids to Mitochondria: Shared Metabolic Alterations in Obesity and Alzheimer's Disease.Cells · 2026Review
- Energy-Metabolism-Enhancing Probiotics Enhance the Therapeutic Response to a Glucagon-like Peptide-1 Receptor Agonist.Nutrients · 2026Article
- ICAM-1 identifies preadipocytes and restricts white adipogenesis by adhering immune cells.Cell death and differentiation · 2026Article
- Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NADCardiovascular diabetology · 2025Article
- Fatty acid composition of lipid fractions in white- and brown-like adipocytes derived from human mesenchymal stem cells.Adipocyte · 2025Article
- From Mechanisms to Diseases: The Succinate-GPR91 Axis in Cardiometabolic Diseases.Journal of cardiovascular translational research · 2025Review
- Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NADResearch square · 2025Article
- Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.Diabetes · 2025Article
- Enhanced fatty acid oxidation via SCD1 downregulation fuels cardiac reprogramming.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- An insight into advances and challenges in the development of potential stearoyl Co-A desaturase 1 inhibitors.RSC advances · 2024Review
- Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.Nature communications · 2024Article
- Effects of Succinate on Growth Performance, Meat Quality and Lipid Synthesis in Bama Miniature Pigs.Animals : an open access journal from MDPI · 2024Article
- Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.Nature metabolism · 2024Article
- Type 2 diabetes and succinate: unmasking an age-old molecule.Diabetologia · 2024Review
- Remodeling of Hepatic Glucose Metabolism in Response to Early Weaning in Piglets.Animals : an open access journal from MDPI · 2024Article
- Feeding citrus pomace fermented with combined probiotics improves growth performance, meat quality, fatty acid profile, and antioxidant capacity in yellow-feathered broilers.Frontiers in veterinary science · 2024Article
- Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral TNature immunology · 2024Article
- Succinate Enhances Lipolysis and Decreases Adipocytes Size in Both Subcutaneous and Visceral Adipose Tissue from High-Fat-Diet-Fed Obese Mice.Foods (Basel, Switzerland) · 2023Article
- Regulation of cell differentiation to promote pullulan synthesis in Aureobasidium pullulans NG.Applied microbiology and biotechnology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Preadipocytes can give rise to either white adipocytes or beige adipocytes. Owing to their distinct abilities in nutrient storage and energy expenditure, strategies that specifically promote "beiging" of adipocytes hold great promise for counterbalancing obesity and metabolic diseases. Yet, factors dictating the differentiation fate of adipocyte progenitors remain to be elucidated. We found that stearoyl-coenzyme A desaturase 1 (Scd1)-deficient mice, which resist metabolic stress, possess augmentation in beige adipocytes under basal conditions. Deletion of Scd1 in mature adipocytes expressing Fabp4 or Ucp1 did not affect thermogenesis in mice. Rather, Scd1 deficiency shifted the differentiation fate of preadipocytes from white adipogenesis to beige adipogenesis. Such effects are dependent on succinate accumulation in adipocyte progenitors, which fuels mitochondrial complex II activity. Suppression of mitochondrial complex II by Atpenin A5 or oxaloacetic acid reverted the differentiation potential of Scd1-deficient preadipocytes to white adipocytes. Furthermore, supplementation of succinate was found to increase beige adipocyte differentiation both in vitro and in vivo. Our data reveal an unappreciated role of Scd1 in determining the cell fate of adipocyte progenitors through succinate-dependent regulation of mitochondrial complex II.
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