ArticleNeuroImage. Clinical2020
Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium.
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66 citing papers in PubMed.
- Transcranial magnetic stimulation regulates brain functional network dynamics in stroke patients: a randomised controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- FUNCTIONAL CONNECTIVITY ALTERATIONS IN MAJOR DEPRESSIVE DISORDER.bioRxiv : the preprint server for biology · 2026Article
- Identifying affective state via clustering of temporal variability in limbic activity and mediating role of negative emotion.Molecular psychiatry · 2026Article
- Comparing local brain activity and distant functional connectivity in transgender women compared to cisgender controls.Scientific reports · 2026Article
- Aberrant dynamic functional architecture in major depressive disorder: Vertex-Wise large-sample fMRI analyses reveal network-specific alterations and symptom associations.Translational psychiatry · 2026Article
- Dynamic Exploration of Resting-State Brain Attractors Altered in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2026Article
- CCPD under sparsity and low-rank constraints: multi-frequency dynamic functional network connectivity analysis in schizophrenia.Frontiers in neuroscience · 2026Article
- Association between usage intensity of short video platforms and altered brain function: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Association of sleep symptom burden with default mode network homogeneity in first-episode drug-naïve adolescents with major depressive disorder.Frontiers in psychiatry · 2026Article
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Dynamic changes in hemispheric lateralization in major depressive disorder correlate with neurotransmitter and genetic profiles: a DIRECT consortium study.Translational psychiatry · 2025Article
- Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination.Human brain mapping · 2025Review
- Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships.bioRxiv : the preprint server for biology · 2025Article
- Random Walk-Based Node Feature Learning for Major Depressive Disorder Identification Through Multi-Site rs-fMRI Data.Human brain mapping · 2025Article
- Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder.Comprehensive psychoneuroendocrinology · 2025Article
- Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression.Journal of neurology · 2025Article
- Functional brain network dynamics of brooding in depression: Insights from real-time fMRI neurofeedback.Journal of affective disorders · 2025Article
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Authors and funding
66 authors.
Yicheng LongDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China; Mental Health Institute, Central South University, Changsha, Hunan 410011, China; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Hengyi CaoDepartment of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, CT 06511, USA. Electronic address: hengyi.cao@yale.edu.
Chaogan YanCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016, USA.
Xiao ChenCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Le LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Francisco Xavier CastellanosDepartment of Child and Adolescent Psychiatry, NYU School of Medicine, New York, NY 10016, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Tongjian BaiThe first affiliated hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Qijing BoBeijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Guanmao ChenThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Ningxuan ChenCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Wei ChenSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
Chang ChengDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Yuqi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Xilong CuiDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Jia DuanDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China.
Yiru FangClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Qiyong GongHuaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Wenbin GuoDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Zhenghua HouDepartment of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China.
Lan HuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li KuangMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Feng LiBeijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Kaiming LiHuaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Tao LiMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Yansong LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China.
Qinghua LuoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huaqing MengDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Daihui PengClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Haitang QiuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing 400716, China.
Yuedi ShenDepartment of Diagnostics, Affiliated Hospital, Medical School, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Yushu ShiDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Tianmei SiNational Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China.
Chuanyue WangBeijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Fei WangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China.
Kai WangThe first affiliated hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Li WangNational Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China.
Xiang WangDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Ying WangThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Xiaoping WuXi'an Central Hospital, Xi'an, Shaanxi 710003, China.
Xinran WuDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chunming XieDepartment of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, China.
Guangrong XieDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Haiyan XieDepartment of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Peng XieInstitute of Neuroscience, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xiufeng XuDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Hong YangDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Jian YangThe First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Jiashu YaoSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
Shuqiao YaoDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Yingying YinDepartment of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China.
Yonggui YuanDepartment of Psychosomatics and Psychiatry, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210096, China.
Aixia ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Hong ZhangXi'an Central Hospital, Xi'an, Shaanxi 710003, China.
Kerang ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Lei ZhangCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhijun ZhangXi'an Central Hospital, Xi'an, Shaanxi 710003, China.
Rubai ZhouClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Yiting ZhouMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Junjuan ZhuClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Chaojie ZouDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Yufeng ZangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 311121, China.
Jingping ZhaoDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.
Calais Kin-Yuen ChanDepartment of Psychology, The University of Hong Kong, Hong Kong 999077, China.
Weidan PuMedical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Zhening LiuDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China; Mental Health Institute, Central South University, Changsha, Hunan 410011, China. Electronic address: zhening.liu@csu.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach.
methodsResting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels.
resultsThe group of MDD patients showed significantly higher temporal variability, lower temporal correlation coefficient (indicating decreased temporal clustering) and shorter characteristic temporal path length (indicating increased temporal efficiency) compared with healthy controls (corrected p < 3.14×10
conclusionsOur findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.
Indexed as
ConnectomeAdolescentAdultAgedBrainFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedNerve NetYoung AdultConnectomeDefault-modeDepressionDynamic functional connectivityFMRITemporal variability
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