Evidence map›Paper›PMID 31953146›Full record

ArticleJournal of molecular biology2020

Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.

Matthew J Walker, Matthew D Shortridge, Dreycey D Albin, Lauren Y Cominsky, Gabriele Varani

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Structural insights into the role of eIF3 in translation mediated by the HCV IRES.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Application of NMR to Large RNAs.Journal of molecular biology · 2025
    Review
  3. Interpretation of RNA Universe and Coding Potential Using IntRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Ins and outs of IRES elements: function and significance.Biochemical Society transactions · 2025
    Review
  5. Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
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  15. Article
  16. HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Secondary structures in RNA synthesis, splicing and translation.Computational and structural biotechnology journal · 2022
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew J WalkerDepartment of Chemistry, University of Washington, Seattle, WA, USA 98195.
Matthew D ShortridgeDepartment of Chemistry, University of Washington, Seattle, WA, USA 98195.
Dreycey D AlbinDepartment of Chemistry, University of Washington, Seattle, WA, USA 98195.
Lauren Y CominskyDepartment of Chemistry, University of Washington, Seattle, WA, USA 98195.
Gabriele VaraniDepartment of Chemistry, University of Washington, Seattle, WA, USA 98195. Electronic address: varani@chem.washington.edu.
University of Washington · US

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
ncRNA: Structure, Interactions and InhibitionR35GM126942 · NIGMS · UNIVERSITY OF WASHINGTON · PI Gabriele Varani · 2018 to 2026
$6.0M
UW Post-Baccalaureate Research Education Program (PREP)R25GM086304 · NIGMS · UNIVERSITY OF WASHINGTON · PI Gabriele Varani · 2011 to 2026
$5.7M
High-resolution modeling of protein-RNA interfacesR01GM121487 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2017 to 2020
$1.7M
Regulation of microRNA processingR01GM103834 · NIGMS · UNIVERSITY OF WASHINGTON · PI VARANI, GABRIELE · 2014 to 2017
$1.1M
Small Angle X-ray Scattering InstrumentS10RR027000 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2011 to 2011
$307k
NCRR NIH HHS S10 RR027000NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R01 GM103834NIGMS NIH HHS R01 GM121487NIGMS NIH HHS R25 GM086304NIGMS NIH HHS R35 GM126942
6 · The paper itself

Abstract

Specialized translation initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs. Similar to internal ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recognition by eIF3d, a new 5'-m

Indexed as

5' Untranslated RegionsInternal Ribosome Entry SitesProtein BiosynthesisEukaryotic Initiation Factor-3HepacivirusHumansJNK Mitogen-Activated Protein KinasesNucleic Acid ConformationPeptide Chain Initiation, TranslationalProtein BindingRibosomesRNA5' Untranslated RegionsEukaryotic Initiation Factor-3Internal Ribosome Entry SitesJNK Mitogen-Activated Protein KinasesRNAeIF3 recognitionIRESNMRRNA structurespecialized translation initiation

Identifiers

PMID31953146
PMCPMC7225069
OpenAlexW2998847868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.