Evidence map›Paper›PMID 31952557›Full record

ArticleComparative medicine2020

Evaluation of Peripheral Blood Markers as Early Endpoint Criteria in Guinea Pigs (

Wendy R Williams, JoLynn Troudt, Elizabeth Creissen, Helle Bielefeldt-Ohmann, Matthew S Johnston, Lon V Kendall, Angelo A Izzo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wendy R WilliamsDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;, Email: wendytuttle@gmail.com.
JoLynn TroudtDepartments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado.
Elizabeth CreissenDepartments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado.
Helle Bielefeldt-OhmannUniversity of Queensland, Australian Infectious Diseases Research Centre, St Lucia, and School of Veterinary Science, Gatton Campus, Queensland, Australia.
Matthew S JohnstonDepartment of Clinical Sciences, Colorado State University, Fort Collins, Colorado.
Lon V KendallDepartments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado.
Angelo A IzzoDepartments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado.

Funding

NIAID NIH HHS HHSN272201000009I
6 · The paper itself

Abstract

The guinea pig model of tuberculosis is used extensively to assess the efficacy of novel tuberculosis vaccines. There are established parameters to determine vaccine efficacy in this model, but the science community currently lacks established biomarkers for early detection and monitoring of experimental disease in guinea pigs. To define a set of biomarkers that could be used as benchmarks for disease progression and early endpoint criteria, we assessed serum biochemical and hematology parameters in 2 groups of guinea pigs-one vaccinated with the attenuated

Indexed as

Guinea PigsAnimalsBiomarkersDisease Models, AnimalDisease ProgressionEndpoint DeterminationFemaleMycobacterium tuberculosisTuberculosis VaccinesBiomarkersTuberculosis Vaccines

Identifiers

PMID31952557
PMCPMC7024781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.