ArticleLipids in health and disease2020
Functional interaction between plasma phospholipid fatty acids and insulin resistance in leucocyte telomere length maintenance.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Exposure to heavy metals and trace elements and risk of dyslipidemia: a nested case-control analysis in rural adults.Frontiers in endocrinology · 2026Article
- The novel nutritional metabolic risk index and established triglyceride-glucose indices in type 2 diabetes: modifying role of biological aging assessed by telomere length.Frontiers in nutrition · 2026Article
- Identification of telomere maintenance-driven molecular subtypes in hepatocellular carcinoma: implications for prognosis and targeted therapy via KPNA2.Discover oncology · 2025Article
- Short leukocyte telomere length and high plasma phospholipid fatty acids increase the risk of type 2 diabetes.Endocrine connections · 2024Article
- Study of association of leptin with leukocyte telomere length in a Chinese rural population.Lipids in health and disease · 2024Article
- The predictive accuracy of coronary heart disease risk prediction models in rural Northwestern China.Preventive medicine reports · 2023Article
- Persistent dyslipidemia increases the longitudinal changes in telomere length.Lipids in health and disease · 2023Article
- Association of telomere length and telomerase methylation with n-3 fatty acids in preschool children with obesity.BMC pediatrics · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious evidence suggests that plasma phospholipid fatty acids (PPFAs) and HOMA insulin resistance (HOMA-IR) are independently related to leukocyte telomere length (LTL). However, there is limited evidence of regarding the effect of their interaction on relative LTL (RLTL). Therefore, here, we aimed to determine the effect of the interaction between PPFAs and HOMA-IR on RLTL.
methodsWe conducted a cross-sectional study, involving a total of 1246 subjects aged 25-74 years. PPFAs and RLTL were measured, and HOMA-IR was calculated. The effect of the interaction between PPFAs and HOMA-IR on RLTL was assessed by univariate analysis, adjusting for potential confounders.
resultsIn age-adjusted analyses, multivariate linear regression revealed a significant association of the levels of elaidic acid, HOMA-IR, monounsaturated fatty acids (MUFA) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) with RLTL. After adjustment of age and gender, race, smoking, drinking, tea, and exercise, elaidic acid, and omega-3 (n-3) PUFA were negatively associated with RLTL, and HOMA-IR and n-6 PUFA were positively associated with RLTL. These associations were not significantly altered upon further adjustment for anthropometric and biochemical indicators. Meanwhile, the effect of the interaction of elaidic acid and HOMA-IR on RLTL was significant, and remained unchanged even after adjusting for the aforementioned potential confounders. Interestingly, individuals who had the lowest HOMA-IR and the highest elaidic acid levels presented the shortest RLTL.
conclusionsOur findings indicated that shorter RLTL was associated with lower HOMA-IR and higher elaidic acid level. These findings might open a new avenue for exploring the potential role of the interaction between elaidic acid and HOMA-IR in maintaining RLTL.
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