Evidence map›Paper›PMID 31952517›Full record

SynthesisJournal of translational medicine2020

Effects of probiotics on type II diabetes mellitus: a meta-analysis.

Yun-Wen Tao, Ying-Luo Gu, Xin-Qi Mao, Lei Zhang, Yu-Fang Pei

Erratum issuedOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 11 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 11 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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  6. Roles of the gut microbiome in weight management.Nature reviews. Microbiology · 2023
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yun-Wen TaoDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China.
Ying-Luo GuDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China.
Xin-Qi MaoDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China.
Lei ZhangCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China. lzhang6@suda.edu.cn.
Yu-Fang PeiDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China. ypei@suda.edu.cn.ORCID http://orcid.org/0000-0002-9157-0759
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of the present study was to evaluate the effectiveness of probiotics on type II diabetes mellitus (T2DM).

methodsWe performed a comprehensive search on PubMed, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journal Databases, Wan Fang database and China biology medicine disc for relevant studies published before June 2019. Glycated hemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR) and fasting blood glucose (FBG) were used as indicators for T2DM. Inverse-variance weighted mean difference (WMD) with 95% confidence interval (CI) was calculated for the mean HbA1c, FBG and HOMA-IR changes from baseline.

results15 randomized controlled trials (RCT) with a total of 902 participants were included into the meta-analysis. Considering the clinical heterogeneity caused by variation of dosage and duration of probiotic treatment, random-effects model was used to estimate the pooled WMD. Significantly greater reduction in HbA1c% (WMD = - 0.24, 95% CI [- 0.44, - 0.04], p = 0.02), FBG (WMD = - 0.44 mmol/L, 95% CI [- 0.74, - 0.15], p = 0.003) and HOMA-IR (WMD = - 1.07, 95% CI [- 1.58, - 0.56], p < 0.00001) were observed in probiotics treated group. Further sensitivity analysis verified the reliability and stability of our results.

conclusionThe results of our meta-analysis indicated that probiotics treatment may reduce HbA1c, FBG and insulin resistance level in T2DM patients. More clinical data and research into the mechanism of probiotics are needed to clarify the role of probiotics in T2DM.

Indexed as

Diabetes Mellitus, Type 2ProbioticsBlood GlucoseChinaGlycated HemoglobinHumansRandomized Controlled Trials as TopicBlood GlucoseGlycated HemoglobinGut microbiotaMeta-analysisProbioticType II diabetes mellitus

Identifiers

PMID31952517
PMCPMC6966830
OpenAlexW3007815550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.