Evidence map›Paper›PMID 31952471›Full record

ArticleBMC genetics2020

Accumulation of genetic variants associated with immunity in the selective breeding of broilers.

Angela Zou, Kerry Nadeau, Pauline W Wang, Jee Yeon Lee, David S Guttman, Shayan Sharif, Doug R Korver, John H Brumell, John Parkinson

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Angela ZouDepartment of Biochemistry, University of Toronto, Toronto, M5S 1A8, ON, Canada.
Kerry NadeauDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada.
Pauline W WangCentre for the Analysis of Genome Evolution & Function, University of Toronto, 25 Willcocks Street, Toronto, M5S 3G5, ON, Canada.
Jee Yeon LeeCentre for the Analysis of Genome Evolution & Function, University of Toronto, 25 Willcocks Street, Toronto, M5S 3G5, ON, Canada.
David S GuttmanCentre for the Analysis of Genome Evolution & Function, University of Toronto, 25 Willcocks Street, Toronto, M5S 3G5, ON, Canada.
Shayan SharifDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, N1G 2W1, ON, Canada.
Doug R KorverDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada.
John H BrumellDepartment of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, ON, Canada.
John ParkinsonDepartment of Biochemistry, University of Toronto, Toronto, M5S 1A8, ON, Canada. jparkin@sickkids.ca.ORCID 0000-0001-9815-1189
University of Toronto · CAUniversity of Alberta · CAUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo satisfy an increasing demand for dietary protein, the poultry industry has employed genetic selection to increase the growth rate of broilers by over 400% in the past 50 years. Although modern broilers reach a marketable weight of ~ 2 kg in a short span of 35 days, a speed twice as fast as a broiler 50 years ago, the expedited growth has been associated with several negative detrimental consequences. Aside from heart and musculoskeletal problems, which are direct consequences of additional weight, the immune response is also thought to be altered in modern broilers.

resultsGiven that identifying the underlying genetic basis responsible for a less sensitive innate immune response would be economically beneficial for poultry breeding, we decided to compare the genomes of two unselected meat control strains that are representative of broilers from 1957 and 1978, and a current commercial broiler line. Through analysis of genetic variants, we developed a custom prioritization strategy to identify genes and pathways that have accumulated genetic changes and are biologically relevant to immune response and growth performance. Our results highlight two genes, TLR3 and PLIN3, with genetic variants that are predicted to enhance growth performance at the expense of immune function.

conclusionsPlacing these new genomes in the context of other chicken lines, reveal genetic changes that have specifically arisen in selective breeding programs that were implemented in the last 50 years.

Indexed as

Genetic VariationSelective BreedingAnimalsChickensDNA Copy Number VariationsGenomeGenomicsImmunityPhylogenyPolymorphism, Single NucleotideSelection, GeneticCommercial broilersGenetic variantsImmune functionPoultry selection

Identifiers

PMID31952471
PMCPMC6969402
OpenAlexW3003958584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.