Evidence map›Paper›PMID 31952332›Full record

ArticleMolecules (Basel, Switzerland)2020

New Zampanolide Mimics: Design, Synthesis, and Antiproliferative Evaluation.

Guanglin Chen, Ziran Jiang, Qiang Zhang, Guangdi Wang, Qiao-Hong Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guanglin ChenDepartment of Chemistry, California State University, Fresno, CA 93740, USA.
Ziran JiangDepartment of Chemistry, California State University, Fresno, CA 93740, USA.
Qiang ZhangDepartment of Chemistry and RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Guangdi WangDepartment of Chemistry and RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Qiao-Hong ChenDepartment of Chemistry, California State University, Fresno, CA 93740, USA.ORCID 0000-0001-6753-1824
California State University, Fresno · USXavier University of Louisiana · US

Funding

Xavier RCMI Renewal Application-Research Infrastructure CoreU54MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI Guangdi Wang, Christopher Williams · 2019 to 2026
$41.9M
Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
Development of Stabilized Zampanolide Mimics as Chemotherapeutics for Prostate CancerSC2GM121185 · NIGMS · CALIFORNIA STATE UNIVERSITY FRESNO · PI CHEN, QIAOHONG · 2017 to 2019
$420k
Foundation for the National Institutes of Health SC2GM121185 and G12MD007595NIGMS NIH HHS SC2 GM121185NIMHD NIH HHS G12 MD007595NIMHD NIH HHS U54 MD007595
6 · The paper itself

Abstract

Zampanolide is a promising microtubule-stabilizing agent (MSA) with a unique chemical structure. It is superior to the current clinically used MSAs due to the covalent nature of its binding to

Indexed as

BiomimeticsCell ProliferationDrug DesignAntineoplastic AgentsDocetaxelDrug Resistance, NeoplasmHumansMacrolidesMaleProstatic NeoplasmsTumor Cells, CulturedAntineoplastic AgentsDocetaxelMacrolideszampanolideanticancer agentnatural productsynthesiszampanolide

Identifiers

PMID31952332
PMCPMC7024368
OpenAlexW3000186643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.