Evidence map›Paper›PMID 31952249›Full record

Trial reportNutrients2020

Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity.

Igor N Sergeev, Thamer Aljutaily, Gemma Walton, Eduardo Huarte

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 10 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 10 syntheses or guidelines pooled it, 307 citations in OpenAlex.

  1. Impacts of Lifestyle and Microbiota-Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  2. ProbioticNarra J · 2025
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  5. Effects ofFrontiers in microbiology · 2025
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  17. Eight Weeks ofNutrients · 2023
    Trial
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Igor N SergeevDepartment of Health and Nutritional Sciences, South Dakota State University, Brookings, SD 57007, USA.
Thamer AljutailyDepartment of Health and Nutritional Sciences, South Dakota State University, Brookings, SD 57007, USA.
Gemma WaltonDepartment of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK.
Eduardo HuarteDepartment of Health and Nutritional Sciences, South Dakota State University, Brookings, SD 57007, USA.
South Dakota State University · USUniversity of Reading · GB

Funding

Sanford Health/SDSU Collaborative Research Seed Grant and the South Dakota BOR R&D Innovation Grant N/A
6 · The paper itself

Abstract

Targeting gut microbiota with synbiotics (probiotic supplements containing prebiotic components) is emerging as a promising intervention in the comprehensive nutritional approach to reducing obesity. Weight loss resulting from low-carbohydrate high-protein diets can be significant but has also been linked to potentially negative health effects due to increased bacterial fermentation of undigested protein within the colon and subsequent changes in gut microbiota composition. Correcting obesity-induced disruption of gut microbiota with synbiotics can be more effective than supplementation with probiotics alone because prebiotic components of synbiotics support the growth and survival of positive bacteria therein. The purpose of this placebo-controlled intervention clinical trial was to evaluate the effects of a synbiotic supplement on the composition, richness and diversity of gut microbiota and associations of microbial species with body composition parameters and biomarkers of obesity in human subjects participating in a weight loss program. The probiotic component of the synbiotic used in the study contained

Indexed as

SynbioticsAdultBifidobacteriumBody CompositionDietary SupplementsDiet, ReducingFemaleGastrointestinal MicrobiomeHumansLactobacillusMaleMiddle AgedObesityWeight Lossbody compositiongut microbiotaobesityobesity biomarkersprebioticprobioticsynbioticweight loss

Identifiers

PMID31952249
PMCPMC7019807
OpenAlexW3000290005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.