ReviewMetabolites2020
Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis.
Review in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
111 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases.International journal of molecular sciences · 2023Pooled it
- Metabolite-Based Genome-Wide Association Studies of Large-Scale Metabolome Analysis to Illustrate Alterations in the Metabolite Landscape of Plants upon Responses to Stresses.Methods in molecular biology (Clifton, N.J.) · 2023Guideline
- Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin-specific quality specification.Journal of the science of food and agriculture · 2026Article
- Beyond Yield: Molecular Crop Quality as a Missing Dimension of Green Chemistry in Sustainable Agriculture.Molecules (Basel, Switzerland) · 2026Review
- Chemical Ontogeny in Plants: Developmental Dynamics of Specialized Metabolism and Implications for Ecology, Quality Control, and Bioprospecting.Plants (Basel, Switzerland) · 2026Review
- Investigation of In Vitro α-Amylase Inhibitory, Antioxidant, Phytochemical Profiling, Molecular Docking, and Swiss ADME Analysis of Magnolia zotictla.Chemistry & biodiversity · 2026Article
- Comparative Metabolite Profiling of Different Solvent Extracts ofMolecules (Basel, Switzerland) · 2026Article
- Advantages of a Multi-Platform Workflow Integrating Biphasic Extraction, Chromatography, and NMR for Characterization of Metabolites in Extracts ofMetabolites · 2026Article
- Integrated Phytochemical and Pharmacological Insights intoPlants (Basel, Switzerland) · 2026Review
- Phytochemical Diversity inPlants (Basel, Switzerland) · 2026Article
- Unveiling the anticancer potential of medicinal plants: metabolomics and analytical tools in phytomedicine.Molecular diversity · 2026Review
- Identification of antigonorrhoeal phytochemical lead compounds using a metabolomics-guided approach.Folia microbiologica · 2026Article
- An archaeo-metabolomics approach for identifying cedar tar in archaeological samples: differentiating plant products and production processes.Scientific reports · 2026Article
- Chemical diversity and species differentiation in Brazilian Vanilla: insights from LC-HRMS/MS metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Comparative Metabolomics and Transcriptomics Analysis ofMolecules (Basel, Switzerland) · 2026Article
- Article
- Identifying Key Metabolites in South African Medicinal Plants Using Dual Electrospray Ionization Metabolomics.Plants (Basel, Switzerland) · 2026Article
- Integrated counter current separation and omics approaches for discovery of bioactive compounds from medicinal plants.Frontiers in pharmacology · 2026Review
- Metabolomic Analysis of Tomato Plants Treated With Garlic Extract,Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Metabolomic-based promising technique for fruit-based natural products analysis.Food chemistry: X · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.