Evidence map›Paper›PMID 31952188›Full record

ArticleInternational journal of molecular sciences2020

Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers.

Daniel Chiumia, Anna-Katharina Hankele, Anna E Groebner, Katy Schulke, Horst-Dieter Reichenbach, Katrin Giller, Valeri Zakhartchenko, Stefan Bauersachs, Susanne E Ulbrich

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Manipulating the Epigenome in Nuclear Transfer Cloning: Where, When and How.International journal of molecular sciences · 2020
    Review
  5. Embryo-Maternal Interactions Underlying Reproduction in Mammals.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Daniel ChiumiaETH Zurich, Animal Physiology, Institute of Agricultural Sciences, 8092 Zurich, Switzerland.
Anna-Katharina HankeleETH Zurich, Animal Physiology, Institute of Agricultural Sciences, 8092 Zurich, Switzerland.
Anna E GroebnerPhysiology Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
Katy SchulkePhysiology Weihenstephan, Technical University of Munich, 85354 Freising, Germany.
Horst-Dieter ReichenbachBavarian State Research Center for Agriculture, Institute of Animal Breeding, 85586 Poing, Grub, Germany.
Katrin GillerETH Zurich, Animal Nutrition, Institute of Agricultural Sciences, 8092 Zurich, Switzerland.ORCID 0000-0002-1276-4548
Valeri ZakhartchenkoChair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians University, 81377 Munich, Germany.
Stefan BauersachsChair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians University, 81377 Munich, Germany.ORCID 0000-0003-2450-1216
Susanne E UlbrichETH Zurich, Animal Physiology, Institute of Agricultural Sciences, 8092 Zurich, Switzerland.ORCID 0000-0003-0355-3869
ETH Zurich · CHTechnical University of Munich · DEBavarian State Research Center for Agriculture · DELudwig-Maximilians-Universität München · DEUniversity of Zurich · CH

Funding

Federal Ministry of Education and Research FUGATOplus- REMEDYGerman Research Foundation UL 350/1-2, FOR 478Society for Reproduction and Fertility FUGATOplus- REMEDYSwiss Government Excellence Scholarship ETHZ VP2015x0836
6 · The paper itself

Abstract

Vascular endothelial growth factor A (VEGFA) plays a critical angiogenic role in the endometrium of placentalia during preimplantation. The role of VEGFA and its receptors is not fully characterised in bovine reproduction. We analysed the mRNA expression of VEGFA isoforms 121, 165 and 189, and VEGF receptors 1 and 2 in three experimental settings (A, B and C). We compared intercaruncular endometrium of cyclic to pregnant heifers at Days 12, 15 and 18 post insemination (Day 0), and between Day 15 and Day 18 conceptuses (A). We further compared caruncular versus intercaruncular endometrium at Day 15 (B), and endometrium of heifers carrying embryos originating from somatic cell nuclear transfer (SCNT) versus in vitro fertilisation (IVF) at Day 18 (C). Endometrial VEGFA protein was localised and quantified. Pregnant heifers displayed lower intercaruncular endometrial mRNA expression of VEGFA-121 (

Indexed as

AnimalsBlastocystCattleEmbryonic DevelopmentEndometriumEstradiolFemaleFertilization in VitroGene Expression Regulation, DevelopmentalNuclear Transfer TechniquesPregnancyProgesteroneProtein IsoformsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1EstradiolProgesteroneProtein IsoformsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1angiogenesisbovineconceptusendometriumIVFSCNT

Identifiers

PMID31952188
PMCPMC7014046
OpenAlexW3000622625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.