Evidence map›Paper›PMID 31951824›Full record

ArticleCell host & microbe2020

Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop.

Lauren Gay, Rolf Renne

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. CITE-Seq Analysis Reveals a Differential Natural Killer CellInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lauren GayDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA.
Rolf RenneDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA; University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA; University of Florida Genetics Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: rrenne@ufl.edu.
University of Florida · USUniversity of Florida Health · US

Funding

"Project 3" MHV68 IncRNA/miRNA interaction in latency and lympomagenesisP01CA214091 · NCI · UNIVERSITY OF FLORIDA · PI Scott A. Tibbetts · 2017 to 2026
$15.9M
Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
The Role of H3.3 histone variant in the pathogenesis of oral Kaposi's SarcomaR01DE026707 · NIDCR · UNIVERSITY OF FLORIDA · PI RENNE, ROLF F · 2018 to 2022
$1.8M
NCI NIH HHS P01 CA214091NIDCR NIH HHS R01 DE026707NIDCR NIH HHS T90 DE021990
6 · The paper itself

Abstract

In this issue of Cell Host & Microbe, Hancock et al., 2020 show that latent HCMV infection, and specifically miR-US5-2, induces TGF-β secretion, which inhibits myelopoiesis in uninfected HPCs. They also show that HCMV-infected cells become resistant to TGF-β signaling through targeting of SMAD3 by miR-UL22-A-3p and -5p.

Indexed as

MicroRNAsCytomegalovirusHematopoietic Stem CellsHumansTransforming Growth Factor betaVirus LatencyMicroRNAsTransforming Growth Factor beta

Identifiers

PMID31951824
PMCPMC9168951
OpenAlexW3000467085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.