Evidence map›Paper›PMID 31951566›Full record

ArticleCell metabolism2020

The Integrated Stress Response: A Central Memory Switch in Down Syndrome.

Susanna Rosi, Elma S Frias

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Susanna RosiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute of Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA. Electronic address: susanna.rosi@ucsf.edu.
Elma S FriasDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, University of California, San Francisco, San Francisco, CA, USA; Department of Biomedical Sciences, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Aging exacerbates trauma-induced immune pathways and neuronal dysfunctionR01AG056770 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSI, SUSANNA · 2017 to 2021
$1.7M
NIA NIH HHS R01 AG056770
6 · The paper itself

Abstract

Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.

Indexed as

Down SyndromeAnimalsDisease Models, AnimalMemoryMiceNeuronal Plasticity

Identifiers

PMID31951566
OpenAlexW2999485480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.