Evidence map›Paper›PMID 31951515›Full record

ArticleMolecular cell2020

Lonely ER Membrane Proteins Travel to the Nucleus to Rest in Peace by the Asi Complex.

Sha Sun, Malaiyalam Mariappan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sha SunDepartment of Cell Biology, Nanobiology Institute, Yale School of Medicine, West Campus, West Haven, CT 06516, USA.
Malaiyalam MariappanDepartment of Cell Biology, Nanobiology Institute, Yale School of Medicine, West Campus, West Haven, CT 06516, USA. Electronic address: malaiyalam.mariappan@yale.edu.

Funding

Retro-proteomics to identify misfolded proteins from the ER and their quality control pathwaysR21AG056800 · NIA · YALE UNIVERSITY · PI MARIAPPAN, MALAIYALAM · 2018 to 2019
$461k
NIA NIH HHS R21 AG056800
6 · The paper itself

Abstract

In a recent issue of Molecular Cell, Natarajan et al. (2020) showed that unassembled ER membrane proteins diffuse to the INM for degradation. The INM-localized Asi E3 ligase complex is sufficient and necessary for recognition and ubiquitination of unassembled ER membrane proteins.

Indexed as

Membrane ProteinsNuclear EnvelopeCell NucleusEndoplasmic ReticulumQuality ControlUbiquitinationMembrane Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.