ArticleeLife2020
Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 citations in OpenAlex.
- Inter-regional interactions uncouple within-region inhibition stabilization and paradoxical responses.bioRxiv : the preprint server for biology · 2026Article
- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.Science advances · 2026Article
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- Characteristics and dynamical signatures of recurrent cortical circuits during context-dependent processing.bioRxiv : the preprint server for biology · 2026Article
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning.Journal of neurophysiology · 2025Article
- Article
- Optogenetic Stimulation Recruits Cortical Neurons in a Morphology-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics.Cell reports · 2024Article
- Sub-threshold neuronal activity and the dynamical regime of cerebral cortex.Nature communications · 2024Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Top-down modulation in canonical cortical circuits with short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Excitation creates a distributed pattern of cortical suppression due to varied recurrent input.Neuron · 2023Article
- Distributing task-related neural activity across a cortical network through task-independent connections.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
GABAergic interneurons can be subdivided into three subclasses: parvalbumin positive (PV), somatostatin positive (SOM) and serotonin positive neurons. With principal cells (PCs) they form complex networks. We examine PCs and PV responses in mouse anterior lateral motor cortex (ALM) and barrel cortex (S1) upon PV photostimulation in vivo. In ALM layer five and S1, the PV response is paradoxical: photoexcitation reduces their activity. This is not the case in ALM layer 2/3. We combine analytical calculations and numerical simulations to investigate how these results constrain the architecture. Two-population models cannot explain the results. Four-population networks with V1-like architecture account for the data in ALM layer 2/3 and layer 5. Our data in S1 can be explained if SOM neurons receive inputs only from PCs and PV neurons. In both four-population models, the paradoxical effect implies not too strong recurrent excitation. It is not evidence for stabilization by inhibition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.