Evidence map›Paper›PMID 31951099›Full record

ReviewAdvanced healthcare materials2020

(De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.

Ava M Obenaus, Molly Y Mollica, Nathan J Sniadecki

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Integrating mechanical sensor readouts into organ-on-a-chip platforms.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ava M ObenausDepartment of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.
Molly Y MollicaDepartment of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
Nathan J SniadeckiDepartment of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0001-6960-4492

Funding

Bioengineering Cardiovascular Training GrantT32EB001650 · NIBIB · UNIVERSITY OF WASHINGTON · PI REGNIER, MICHAEL · 2004 to 2019
$3.6M
A HUMAN IPSC-BASED 3D MICROPHYSIOLOGICAL SYSTEM FOR MODELING CARDIAC DYSFUNCTION IN MICROGRAVITYUG3EB028094 · NIBIB · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2018 to 2019
$1.5M
Effect of slip bonds due to type 2B von Willebrand Disease on platelet adhesion, aggregation, and contractile forcesF31HL156697 · NHLBI · UNIVERSITY OF WASHINGTON · PI OBENAUS, AVA MARIE · 2021 to 2023
$128k
Connecting Sex to Platelet Function after Mechanical ActivationF31HL147462 · NHLBI · UNIVERSITY OF WASHINGTON · PI MOLLICA, MOLLY YEANDEL · 2019 to 2021
$118k
NHLBI NIH HHS F31 HL147462NHLBI NIH HHS F31 HL156697NIBIB NIH HHS T32 EB001650NIBIB NIH HHS UG3 EB028094
6 · The paper itself

Abstract

The ability for biological cells to produce mechanical forces is important for the development, function, and homeostasis of tissue. The measurement of cellular forces is not a straightforward task because individual cells are microscopic in size and the forces they produce are at the nanonewton scale. Consequently, studies in cell mechanics rely on advanced biomaterials or flexible structures that permit one to infer these forces by the deformation they impart on the material or structure. Herein, the scientific progression on the use of deformable materials and deformable structures to measure cellular forces are reviewed. The findings and insights made possible with these approaches in the field of cell mechanics are summarized.

Indexed as

Mechanical PhenomenaMechanotransduction, Cellularcell mechanicsmicropoststraction force microscopy (TFM)traction forces

Identifiers

PMID31951099
PMCPMC7274881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.