Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials.

Todd W Rice, Sunil Kripalani, Christopher J Lindsell

Abstract readComment

In one paragraph

Article in JAMA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Contextual factors related to ventilator mode during an embedded randomized trial: a longitudinal survey of clinicians.BMC health services research · 2026
Trial
Different dosages of vonoprazan for gastroesophageal reflux disease: study protocol for a pragmatic, crossover-cluster, randomized controlled trial with patient preference arms.Trials · 2023
Article
REVISE:BMJ open · 2023
Article
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.The Lancet. Respiratory medicine · 2022
Review
Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damageWorld journal of gastroenterology · 2020
Article
Opportunities and challenges of clustering, crossing over, and using registry data in the PEPTIC trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020
Article

4 · The record

Corrections and comments

Comment on
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.2020

5 · Who and what money

Authors and funding

3 authors.

Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Sunil KripalaniDivision of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Christopher J LindsellCenter for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, Tennessee.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026

$130.7M

NCATS NIH HHS UL1 TR002243

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Critical IllnessProton Pump InhibitorsHistamineHistamine H2 AntagonistsHospital MortalityHumansIntensive Care UnitsRespiration, ArtificialUlcerHistamineHistamine H2 AntagonistsProton Pump Inhibitors

Identifiers

PMID31950973

DOI10.1001/jama.2019.22436

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.