Evidence map›Paper›PMID 31950732›Full record

ArticleClinical pharmacology in drug development2020

Effects of Lasmiditan on Cardiovascular Parameters and Pharmacokinetics in Healthy Subjects Receiving Oral Doses of Propranolol.

Max Tsai, Michael Case, Paul Ardayfio, Helen Hochstetler, Darren Wilbraham

Open access · hybridAbstract readClinical Trial, Phase IComparative Study
In one paragraph

Article in Clinical pharmacology in drug development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. The 5-HTNature reviews. Neurology · 2023
    Review
  3. Review
  4. Review
  5. Lasmiditan: Acute Migraine Treatment Without Vasoconstriction. A Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2021
    Review
  6. Article
  7. Review
  8. Review
  9. The potential of lasmiditan in migraine.Therapeutic advances in neurological disorders · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Max TsaiEli Lilly and Company, Indianapolis, Indiana, USA.
Michael CaseEli Lilly and Company, Indianapolis, Indiana, USA.
Paul ArdayfioEli Lilly and Company, Indianapolis, Indiana, USA.
Helen HochstetlerEli Lilly and Company, Indianapolis, Indiana, USA.
Darren WilbrahamEli Lilly and Company, Indianapolis, Indiana, USA.
Eli Lilly (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lasmiditan (LY573144/COL-144) is a high-affinity, centrally penetrant, selective 5-HT

Indexed as

Administration, OralAdrenergic beta-AntagonistsAdultAgedBenzamidesBlood PressureCardiovascular SystemDrug InteractionsDrug Therapy, CombinationFastingFemaleHealthy VolunteersHeart RateHumansMaleMiddle AgedAdrenergic beta-AntagonistsBenzamideslasmiditanPiperidinesPropranololPyridinesSerotonin Receptor Agonistscardiovascular effectsdrug-drug interactionlasmiditanmigrainepharmacokineticspropranololvasoconstriction

Identifiers

PMID31950732
PMCPMC7384162
OpenAlexW3000360078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.