Evidence map›Paper›PMID 31950512›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2020

Harmonizing behavioral outcomes across studies, raters, and countries: application to the genetic analysis of aggression in the ACTION Consortium.

Justin M Luningham, Anne M Hendriks, Eva Krapohl, Hill Fung Ip, Catharina E M van Beijsterveldt, Sebastian Lundström, Eero Vuoksimaa, Tellervo Korhonen, Paul Lichtenstein, Robert Plomin and 6 more

Open access · bronzeAbstract readMulticenter StudyTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 5 countries.

Justin M LuninghamDepartment of Psychology, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0002-5037-9149
Anne M HendriksNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Eva KrapohlMedical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Hill Fung IpNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Catharina E M van BeijsterveldtNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sebastian LundströmGillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.
Eero VuoksimaaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Tellervo KorhonenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Robert PlominMedical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Lea PulkkinenDepartment of Psychology, University of Jyvaskyla, Jyvaskyla, Finland.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Meike BartelsNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
Gitta H LubkeDepartment of Psychology, University of Notre Dame, Notre Dame, IN, USA.
University of Helsinki · FIVrije Universiteit Amsterdam · NLAmsterdam Neuroscience · NLKing's College London · GBUniversity of Notre Dame · USIndiana University Bloomington · USKarolinska Institutet · SEUniversity of Gothenburg · SEUniversity of Jyväskylä · FI

Funding

Psychometric and Genetic Assessments of Substance UseR37DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2005 to 2014
$3.7M
Psychometric and Genetic Assessments of Substance UseR01DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2004 to 2019
$2.3M
Medical Research Council G19/2Medical Research Council MR/M021475/1NIDA NIH HHS R01 DA018673NIDA NIH HHS R37 DA018673NIH HHS DA-018673
6 · The paper itself

Abstract

backgroundAggression in children has genetic and environmental causes. Studies of aggression can pool existing datasets to include more complex models of social effects. Such analyses require large datasets with harmonized outcome measures. Here, we made use of a reference panel for phenotype data to harmonize multiple aggression measures in school-aged children to jointly analyze data from five large twin cohorts.

methodsIndividual level aggression data on 86,559 children (42,468 twin pairs) were available in five European twin cohorts measured by different instruments. A phenotypic reference panel was collected which enabled a model-based phenotype harmonization approach. A bi-factor integration model in the integrative data analysis framework was developed to model aggression across studies while adjusting for rater, age, and sex. Finally, harmonized aggression scores were analyzed to estimate contributions of genes, environment, and social interaction to aggression. The large sample size allowed adequate power to test for sibling interaction effects, with unique dynamics permitted for opposite-sex twins.

resultsThe best-fitting model found a high level of overall heritability of aggression (~60%). Different heritability rates of aggression across sex were marginally significant, with heritability estimates in boys of ~64% and ~58% in girls. Sibling interaction effects were only significant in the opposite-sex twin pairs: the interaction effect of males on their female co-twin differed from the effect of females on their male co-twin. An aggressive female had a positive effect on male co-twin aggression, whereas more aggression in males had a negative influence on a female co-twin.

conclusionsOpposite-sex twins displayed unique social dynamics of aggressive behaviors in a joint analysis of a large, multinational dataset. The integrative data analysis framework, applied in combination with a reference panel, has the potential to elucidate broad, generalizable results in the investigation of common psychological traits in children.

Indexed as

AggressionInternationalityChildFemaleHumansMalePhenotypeSiblingsTwinsTwins, DizygoticTwins, MonozygoticAggressiondevelopmental psychopathologyintegrative data analysisphenotype reference paneltwin modeling

Identifiers

PMID31950512
PMCPMC7363537
OpenAlexW2999212989

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.