Evidence map›Paper›PMID 31950494›Full record

ArticleThe Journal of comparative neurology2020

Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse.

Kenichiro Negishi, Mikayla A Payant, Kayla S Schumacker, Gabor Wittmann, Rebecca M Butler, Ronald M Lechan, Harry W M Steinbusch, Arshad M Khan, Melissa J Chee

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  8. Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Slow-Timescale Regulation of Dopamine Release and Mating Drive Over Days.bioRxiv : the preprint server for biology · 2025
    Article
  10. Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons.The Journal of comparative neurology · 2025
    Article
  12. Review
  13. Article
  14. Zona incerta: from Parkinson's disease to addiction.Frontiers in neural circuits · 2025
    Article
  15. Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Article
  17. Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Kenichiro NegishiUTEP Systems Neuroscience Laboratory, Department of Biological Sciences, and Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas.
Mikayla A PayantDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Kayla S SchumackerDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Gabor WittmannDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0003-0747-6813
Rebecca M ButlerDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Ronald M LechanDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0003-0404-2323
Harry W M SteinbuschDepartment of Psychiatry and Neuropsychology, Section Cellular Neuroscience, Maastricht University, Maastricht, Netherlands.ORCID 0000-0002-7667-0604
Arshad M KhanUTEP Systems Neuroscience Laboratory, Department of Biological Sciences, and Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas.ORCID 0000-0003-0254-3546
Melissa J CheeDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.ORCID 0000-0003-3815-9095
Carleton University · CAThe University of Texas at El Paso · USTufts Medical Center · USMaastricht University · NL

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI ARSHAD M. KHAN · 2019 to 2026
$35.1M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
Interrogating brain circuits that control feeding caused by fasting or by cravingSC1GM127251 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI KHAN, ARSHAD M. · 2018 to 2021
$1.4M
Identifying and mapping functional connections of feeding control neurons in theSC3GM109817 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI KHAN, ARSHAD M. · 2014 to 2017
$441k
NIGMS NIH HHS SC1 GM127251NIGMS NIH HHS SC3 GM109817NIMHD NIH HHS G12 MD007592NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

The hypothalamus contains catecholaminergic neurons marked by the expression of tyrosine hydroxylase (TH). As multiple chemical messengers coexist in each neuron, we determined if hypothalamic TH-immunoreactive (ir) neurons express vesicular glutamate or GABA transporters. We used Cre/loxP recombination to express enhanced GFP (EGFP) in neurons expressing the vesicular glutamate (vGLUT2) or GABA transporter (vGAT), then determined whether TH-ir neurons colocalized with native EGFP

Indexed as

AnimalsFemaleHypothalamusMaleMiceNeuronsTyrosine 3-MonooxygenaseVesicular Glutamate Transport ProteinsVesicular Inhibitory Amino Acid Transport ProteinsTyrosine 3-Monooxygenasevesicular GABA transporterVesicular Glutamate Transport ProteinsVesicular Inhibitory Amino Acid Transport ProteinsatlascatecholaminedopamineGABAhypothalamustyrosine hydroxylasezona incerta

Identifiers

PMID31950494
PMCPMC7993550
OpenAlexW2998841239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.