ReviewHead and neck pathology2020
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region.
Review in Head and neck pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Undifferentiated High-Grade Pleomorphic Sarcoma of the Posterior Mandible: A Report of a Rare Case.Cureus · 2026Article
- Epulis: A Narrative Review of Epidemiology, Clinical Features, Pathogenesis, and Management.Oral health & preventive dentistry · 2025Review
- Tenosynovial giant cell tumours of the foot and ankle: a retrospective single centre experience with surgical treatment of 34 cases.BMC cancer · 2025Article
- Giant cell-rich osteosarcoma of the lumbar spine - A rare entity.SA journal of radiology · 2024Article
- Real-world drug utilization and treatment patterns in patients with tenosynovial giant cell tumors in the USA.Future oncology (London, England) · 2024Observational
- Ectopic Intrathyroidal Parathyroid Adenoma Presenting With Osteoporotic Fractures in a Young Man: A Case Report.Cureus · 2023Article
- Aneurysmal bone cyst: a review.Journal of pathology and translational medicine · 2023Review
- Article
- Case report: a giant cell-rich gnathic bone lesion in a child with pycnodysostosis.Frontiers in oral health · 2023Article
- Spinal giant cell-rich osteosarcoma-diagnostic dilemma and treatment strategy: A case report.World journal of clinical cases · 2022Article
- Clinical and Radiologic Response of Central Giant Cell Granuloma to Denosumab: A 6-Year Prospective Observational Study.Calcified tissue international · 2022Observational
- The clinical challenges and dilemma in the management of uncommon maxillary sinus tumors - A report of two cases.Journal of oral and maxillofacial pathology : JOMFP · 2022Article
- Computed tomography and magnetic resonance imaging characteristics of giant cell tumors in the temporomandibular joint complex.Imaging science in dentistry · 2021Article
- Giant cell tumor in the thyroid area: a case report in the novel location and review of literature.Gland surgery · 2021Article
- FNAC Diagnosis Giant Cell Reparative Granuloma of the Orbit Masquerading as Malignancy.Journal of cytologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant cell-rich lesions represent a heterogeneous group of tumors and non-neoplastic lesions, usually arising in bone, which harbor varying number of reactive osteoclastic-type multinucleate giant cells as a common feature. Among these entities, some are confined to the head and neck region (e.g., central giant cell granuloma and mimicking lesions, i.e., peripheral giant cell granuloma and cherubism) or show a relative predilection for this region (e.g., aneurysmal bone cyst and brown tumor of hyperparathyroidism), while others are rare but associated with distinct underlying disease (e.g., giant cell tumor of bone) or histology (e.g., tenosynovial giant cell tumor of the temporomandibular joint and phosphaturic mesenchymal tumor of the jaws) when occurring in the head and neck. Collectively, these lesions pose great challenge in the pathologic diagnosis, which often requires combinatory assessment from the clinical, histopathologic, and/or molecular aspects. This review provides a summary of pertinent clinical and pathologic features and an update of recent molecular and genetic findings of these entities. The considerations in differential diagnosis as well as the effects of the emerging therapeutic RANKL-antagonizing antibody denosumab will also be addressed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.