ArticleBrain imaging and behavior2020
Cortical 3-hinges could serve as hubs in cortico-cortical connective network.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- DEEP-GYRALNET: ENABLING MACHINE LEARNING IN GYRAL FOLDING PATTERN EXTRACTION ON CORTICAL SURFACE.Proceedings. IEEE International Symposium on Biomedical Imaging · 2026Article
- A Unified Continuous Staging Framework for Alzheimer's Disease and Lewy Body Dementia via Hierarchical Anatomical Features.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- USING STRUCTURAL SIMILARITY AND KOLMOGOROV-ARNOLD NETWORKS FOR ANATOMICAL EMBEDDING OF CORTICAL FOLDING PATTERNS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- UNSUPERVISED CORTICAL SURFACE REGISTRATION NETWORK FOR ALIGNING GYRALNET.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- Learning lifespan brain anatomical correspondence via cortical developmental continuity transfer.Medical image analysis · 2025Article
- Unique longitudinal contributions of sulcal interruptions to reading acquisition in children.bioRxiv : the preprint server for biology · 2024Article
- MILD COGNITIVE IMPAIRMENT CLASSIFICATION USING A NOVEL FINER-SCALE BRAIN CONNECTOME.Proceedings. IEEE International Symposium on Biomedical Imaging · 2024Article
- ENHANCING GROUP-WISE CONSISTENCY IN 3-HINGE GYRUS MATCHING VIA ANATOMICAL EMBEDDING AND STRUCTURAL CONNECTIVITY OPTIMIZATION.Proceedings. IEEE International Symposium on Biomedical Imaging · 2024Article
- On presentation of the human cerebral sulci from inside of the cerebrum.Journal of anatomy · 2023Article
- Cortex2vector: anatomical embedding of cortical folding patterns.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Identification for the cortical 3-Hinges folding pattern based on cortical morphological and structural features.Frontiers in neuroscience · 2023Article
- Gyral peaks: Novel gyral landmarks in developing macaque brains.Human brain mapping · 2022Article
- On the definition, construction, and presentation of the human cerebral sulci: A morphology-based approach.Journal of anatomy · 2022Article
- Fundamental functional differences between gyri and sulci: implications for brain function, cognition, and behavior.Psychoradiology · 2021Review
- Mechanism Exploration of 3-Hinge Gyral Formation and Pattern Recognition.Cerebral cortex communications · 2021Article
- Identifying Cross-individual Correspondences of 3-hinge Gyri.Medical image analysis · 2020Article
- Fine-scale individualized gyral folding-based cortical similarity networks reveal distinct organizational patterns in Alzheimer's disease and Lewy body dementia.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as 'connector' hubs rather than 'provincial' hubs and they account for a dominant proportion of nodes in the high-level 'backbone' of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function.
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