ArticleProtein & cell2020
αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model.
Abstract readLetter
In one paragraph
Article in Protein & cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation.Journal of orthopaedic translation · 2026Article
- Metabolomics and Network Pharmacology Analyses Reveal the Mechanism of Moxibustion in Knee Osteoarthritis.Combinatorial chemistry & high throughput screening · 2026Article
- Analysis of miR-151a-3p as a biomarker of osteoarthritis and its clinical value.Journal of orthopaedic surgery and research · 2025Article
- Matrix stiffness in osteoarthritis: from mechanism introduction to biomaterial-based therapies.Frontiers in endocrinology · 2025Review
- Attenuation of osteoarthritis progression via locoregional delivery of Klotho-expressing plasmid DNA and Tanshinon IIA through a stem cell-homing hydrogel.Journal of nanobiotechnology · 2024Article
- α-klotho reduces susceptibility to osteoarthritis: evidence from cross-sectional studies and Mendelian randomization.Frontiers in endocrinology · 2024Article
- Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007-2016.PloS one · 2024Article
- Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity.Nature communications · 2023Article
- Women's contribution to stem cell research for osteoarthritis: an opinion paper.Frontiers in cell and developmental biology · 2023Review
- Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration.Cell research · 2021Article
- Treating osteoarthritis via gene therapy with rejuvenation factors.Gene therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Paloma Martinez-RedondoGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Isabel Guillen-GuillenGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Noah DavidsohnWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, 02115, USA.
Chao WangGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Javier PrietoGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Masakazu KuritaGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Fumiyuki HatanakaGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Cuiqing ZhongGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Reyna Hernandez-BenitezGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Tomoaki HishidaGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Takashi LezakiGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Akihisa SakamotoGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Amy N NemethGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Yuriko HishidaGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Concepcion Rodriguez EstebanGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Kensaku ShojimaGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Ling HuangIntegrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Maxim ShokhirevIntegrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Estrella Nuñez-DelicadoUniversidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, No 135 12, 30107, Guadalupe, Spain.
Josep M CampistolHospital Clinic of Barcelona, Career Villarroel, 170, 08036, Barcelona, Spain.
Isabel Guillen-VicenteDepartment of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain.
Elena Rodriguez-IñigoDepartment of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain.
Juan Manuel Lopez-AlcorochoDepartment of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain.
Marta Guillen-VicenteDepartment of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain.
George ChurchWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, 02115, USA.
Pradeep ReddyGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Pedro Guillen-GarciaDepartment of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain. pedroguillen612@gmail.com.
Guang-Hui LiuNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ibp.ac.cn.
Juan Carlos Izpisua BelmonteGene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. belmonte@salk.edu.ORCID 0000-0003-0557-8875
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCartilage, ArticularCell Culture TechniquesChondrocytesGlucuronidaseHumansKlotho ProteinsOsteoarthritis, KneePapainRatsReceptor, Transforming Growth Factor-beta Type IIRecombinant ProteinsGlucuronidaseKlotho ProteinsPapainReceptor, Transforming Growth Factor-beta Type IIRecombinant Proteins
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.