ArticleVirchows Archiv : an international journal of pathology2020
Clinicopathologic analysis of upper urinary tract carcinoma with variant histology.
Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Desmoplastic reaction at the invasive front of upper urinary tract urothelial carcinoma: prognostic impact and associations with tumour invasiveness and immune-inflammatory status.Virchows Archiv : an international journal of pathology · 2026Article
- Genomic Characterization of Urothelial Carcinoma and Sarcomatoid Carcinoma of the Upper Urinary Tract.Cancers · 2026Article
- The "perfect storm" in bladder oncology: a case of diverticular carcinoma with plasmacytoid features and its clinical ramifications.BMC urology · 2026Article
- Successful multidisciplinary management of non-muscle-invasive upper tract urothelial carcinoma in a patient with HIV and concurrent staghorn calculus: a case report.AIDS research and therapy · 2026Article
- Review
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- Giant cell carcinoma of the urinary bladder : Clinicopathologic analysis and oncological outcomes.Virchows Archiv : an international journal of pathology · 2024Article
- Clear Cell Renal Cell Carcinoma with Prominent Micropapillary Pattern: A Case Report of a Previously Undescribed Morphology.International journal of surgical pathology · 2024Article
- Evaluation of histological variants of upper tract urothelial carcinoma as prognostic factor after radical nephroureterectomy.World journal of urology · 2024Article
- The impact of histological variants in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.Journal of cancer research and clinical oncology · 2023Article
- Case report: Urothelial carcinoma of the renal pelvis with trophoblastic differentiation: A rare case report and review of literature.Pathology oncology research : POR · 2023Review
- Survival Impact of Variant Histology Diagnosis in Upper Tract Urothelial Carcinoma.The Journal of urology · 2022Article
- Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma-like carcinoma of the renal pelvis.Molecular oncology · 2022Article
- [Correlation between daily fluid intake behavioral habits and pathological characteristics of upper tract urothelial carcinoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Impact of Adjuvant Chemotherapy on Variant Histology of Upper Tract Urothelial Carcinoma: A Propensity Score-Matched Cohort Analysis.Frontiers in oncology · 2022Article
- Article
- Tumor budding in upper urinary tract urothelial carcinoma: a putative prognostic factor for extraurothelial recurrence and overall survival.Virchows Archiv : an international journal of pathology · 2021Article
- Unusual Faces of Bladder Cancer.Cancers · 2020Review
- Microcystic urothelial carcinoma: a case report.International journal of clinical and experimental pathology · 2020Article
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Authors and funding
12 authors at 6 institutions in 5 countries.
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Abstract
We report on the clinicopathologic features of 115 cases of high-grade urothelial carcinoma of the upper urinary tract with variant histology present in 39 (34%). Variant histology was typically seen in high pathological stage (pT2-pT4) (82%, 32 cases) patients with lower survival rate (70%, 27 cases, median survival 31 months) and consisted in urothelial with one (23%), two (3%), and three or more variants (3%); 4% of cases presented with pure variant histology. Squamous divergent differentiation was the most common variant (7%) followed by sarcomatoid (6%) and glandular (4%), followed by 3% each of micropapillary, diffuse-plasmacytoid, inverted growth, clear cell glycogenic, or lipid-rich. The pseudo-angiosarcomatous variant is seen in 2%, and 1% each of nested, giant-cell, lymphoepithelioma-like, small-cell, trophoblastic, rhabdoid, microcystic, lymphoid-rich stroma, or myxoid stroma/chordoid completed the study series. Loss of mismatch repair protein expression was identified in one case of upper urinary tract carcinoma with inverted growth variant (3.6%). Variant histology was associated to pathological stage (p = 0.007) and survival status (p = 0.039). The univariate survival analysis identified variant histology as a feature of lower recurrence-free survival (p = 0.046). Our findings suggest that variant histology is a feature of aggressiveness in urothelial carcinoma of the upper urinary tract worth it to be reported.
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