ArticleAnalytical and bioanalytical chemistry2020
Flow-based regenerable chemiluminescence receptor assay for the detection of tetracyclines.
Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Production of RPSLFood chemistry: X · 2025Article
- A reverse ELISA based on quantum dot-labeled TetR for rapid detection of tetracycline.Mikrochimica acta · 2025Article
- A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy.Practical laboratory medicine · 2024Article
- Identification and Evolution of a Natural Tetr Protein Based on Molecular Docking and Development of a Fluorescence Polari-Zation Assay for Multi-Detection of 10 Tetracyclines in Milk.Foods (Basel, Switzerland) · 2022Article
- Concentration-dependent photoluminescence carbon dots for visual recognition and detection of three tetracyclines.Analytical and bioanalytical chemistry · 2021Article
- Integration of 3D Hydrodynamic Focused Microreactor with Microfluidic Chemiluminescence Sensing for Online Synthesis and Catalytical Characterization of Gold Nanoparticles.Sensors (Basel, Switzerland) · 2021Article
- Flow-based System: A Highly Efficient Tool Speeds Up Data Production and Improves Analytical Performance.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- Synthetic Biology-Empowered Hydrogels for Medical Diagnostics.Advances in biochemical engineering/biotechnology · 2021Article
- Emerging biosensors in detection of natural products.Synthetic and systems biotechnology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
For the first time, a flow-based regenerable chemiluminescence receptor assay is established that is eminently suited as screening method for the detection of widely used tetracyclines (TCs) in environmental and food samples. The complex functionality and high reactivity of TCs complicate the creation of immunogens which is currently the bottleneck for developing sensitive immunoassays. In this case, competitive bioreceptor assays for the analysis of small organic molecules are preferable and, moreover, flow-based regenerable bioassays are optimally suited for automated analysis applications. Therefore, the solution for rapid and sensitive analysis of TCs is the regenerable CL receptor assay with a covalently immobilized DNA oligonucleotide containing the specific operator sequence tetO to which the repressor protein TetR binds only in the absence of TCs. The TC measurements are performed on the CL microarray analysis platform MCR 3 within 30 min per sample. The LoD in spiked tap water was determined to be 0.1 μg L
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Registered trials
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