Evidence map›Paper›PMID 31950222›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Enhanced anticancer activity of combined treatment of imatinib and dipyridamole in solid Ehrlich carcinoma-bearing mice.

Alaa E El-Sisi, Samia S Sokar, Hanaa A Ibrahim, Sally E Abu-Risha

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alaa E El-SisiDepartment of Pharmacology and Toxicology, college of pharmacy, University of Tanta, Tanta, Gharbia Governorate, Egypt.
Samia S SokarDepartment of Pharmacology and Toxicology, college of pharmacy, University of Tanta, Tanta, Gharbia Governorate, Egypt.
Hanaa A IbrahimDepartment of Pharmacology and Toxicology, college of pharmacy, University of Tanta, Tanta, Gharbia Governorate, Egypt. hanaa.abdelkareem@pharm.tanta.edu.eg.
Sally E Abu-RishaDepartment of Pharmacology and Toxicology, college of pharmacy, University of Tanta, Tanta, Gharbia Governorate, Egypt.
Tanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study was designed to evaluate potential enhancement of the anticancer activity of imatinib mesylate (IM) with dipyridamole (DIP) and to investigate the underlying mechanisms of the combined therapy (IM/DIP) to reduce hepatotoxicity of IM in solid Ehrlich carcinoma (SEC)-bearing mice. SEC was induced in female albino mice as a model for experimentally induced breast cancer. Mice were randomly divided into seven groups (n = 10): SEC vehicle, IM

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Carcinoma, Ehrlich TumorCaspase 3Cell Line, TumorDipyridamoleDrug Therapy, CombinationFemaleHumansImatinib MesylateMiceProto-Oncogene Proteins c-bcl-2Tumor BurdenVascular Endothelial Growth Factor AATP Binding Cassette Transporter, Subfamily B, Member 1Caspase 3DipyridamoleImatinib MesylateProto-Oncogene Proteins c-bcl-2Vascular Endothelial Growth Factor ADipyridamoleEhrlich carcinomaHepatotoxicityImatinib MesylateMDR-1, p-GP

Identifiers

PMID31950222
OpenAlexW2998802717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.