Evidence map›Paper›PMID 31950015›Full record

ArticleInternational cancer conference journal2020

Complete response to combination therapy with nivolumab and ipilimumab for metastatic collecting duct carcinoma of the kidney.

Kyohei Watanabe, Takayuki Sugiyama, Atsushi Otsuka, Hideaki Miyake

Open access · greenAbstract read
In one paragraph

Article in International cancer conference journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kyohei WatanabeDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Takayuki SugiyamaDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Atsushi OtsukaDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Hideaki MiyakeDepartment of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.ORCID 0000-0003-0563-4160
Hamamatsu University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collecting duct carcinoma (CDC) of the kidney is a rare subtype of renal cell carcinoma (RCC) arising from the distal collecting tubules, characterized by an aggressive phenotype, unfavorable response to several types of systemic agent and a poor prognosis. Recently, treatments with immune checkpoint inhibitors have been widely performed for patients with metastatic RCC; however, no data are available regarding the impact of first-line combination therapy with nivolumab and ipilimumab on metastatic CDC. Here, we report a CDC patient with multiple lymph node metastases who underwent cytoreductive open nephrectomy and subsequently, received nivolumab and ipilimumab therapy. Following four courses of this combined therapy, all nodal metastases had shrunk to < 1 cm in diameter, and thus this patient was judged to show a complete response (CR). To our knowledge, this is the first reported case of a patient with metastatic CDC achieving a CR to combined treatment with nivolumab and ipilimumab, which could be a promising first-line therapy against metastatic CDC.

Indexed as

Complete responseIpilimumabMetastatic collecting duct carcinomaNivolumab

Identifiers

PMID31950015
PMCPMC6942607
OpenAlexW2975262475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.